DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and slc22a13b

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_017209322.1	Gene:	slc22a13b / 556601	ZFINID:	ZDB-GENE-061013-532	Length:	549	Species:	Danio rerio

Alignment Length:	595	Identity:	193/595 - (32%)
Similarity:	295/595 - (49%)	Gaps:	61/595 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCH----VPELDGLDVE 130
            :||..||..:||||.:||.|.:.:...:.|.||..|.|:| |.|...|:|:    :.:...|..|
Zfish     2 IDFTQILSSVGEFGAFQKRLLVAVCLPNIFTAFHMFGQVF-TAISFPHYCNSSWILRQAPNLTEE 65

  Fly   131 ARLALSIPM-TNGEYNNCYMY---DVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVA 191
            .:|.|::|: :.|:|.:|.|:   :::..||...|....      ..|..||.|...: ..:|:.
Zfish    66 KQLNLTVPLDSKGQYESCKMFTPVEMDIEDIEHYGINTT------TSCIDGWVYKAPK-DSSTLI 123

  Fly   192 TEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFW 256
            ||.:.||::......:|||:..|.:||.||||.:||::||..|.:.:..:..|:|||.||..|.:
Zfish   124 TEFDLVCENKVYSEASQSIYMAGLLVGALLFGPMADKYGRRFATLLSLFLQFLSGVGVAFSPNIY 188

  Fly   257 EFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLL 321
            .:..:||.||..........::|..|:.|...|.....:|...|..| ..||..:||.:.:|::|
Zfish   189 VYIALRFVVGTTISGISINTFVLGTEWCGSAKRALFTILSHCFFAIG-LMLLSGVAYGIRNWRVL 252

  Fly   322 AIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQ 386
            .:|.|||:.|.....:::|||||||::|||:|.|...:.|..:.|||:|          |...:.
Zfish   253 QLVLSAPVGLFFIYYWILPESARWLLTQGKLDSAKREILKAARINGRKV----------SENLLD 307

  Fly   387 EQEAQNGKYS--VLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTE 449
            :.||:|...|  ::|||:...||:..|::..:|...|||:.|...|||:.||||:.|..:....|
Zfish   308 KMEAENTAKSSTMIDLFRVGYLRKRALIMCYMWFVTSLVYYGVSLNVGNFGLDIYLTQLIFGMAE 372

  Fly   450 LPADTLLTVILDRFGRRWLACSSMV--LSGVFSLLATVVPV--GIYSAALAIMGRFFVNISYNIG 510
            .||......::.|||||  .|.|:|  |.|...|:...:|.  .|....:|::|:|.:..|::|.
Zfish   373 FPARLSCFPLIQRFGRR--ICQSVVLLLGGTACLIIPAIPAKYPIVVTVIAVIGKFSLAASFSIV 435

  Fly   511 LQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPE 575
            ..:.||:.|||||...|....:...||.|:||.:..|.....|:|:||.|.|..:||.|..||||
Zfish   436 YVYTAELYPTVVRQNGVGLNSMCARVAGILAPLIGLLDVYHHAIPMIIYGSLPFVGGALTFLLPE 500

  Fly   576 TLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEVRSQAFVRGTQTGASLNAS 640
            |||..|             |...|.|.         ||  :..|.||:.:.:  |.:.|.....|
Zfish   501 TLNTDL-------------QDHTDIPA---------DE--SMTVTEVKLERW--GRRRGWDRERS 539

  Fly   641 TGGELRSSIL 650
            |..:.:|..|
Zfish   540 TSQDFKSGRL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	158/485 (33%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	119/344 (35%)
slc22a13b	XP_017209322.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850