DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and slc22a15

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001103169.1	Gene:	slc22a15 / 555262	ZFINID:	ZDB-GENE-070928-5	Length:	497	Species:	Danio rerio

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	232/525 - (44%)	Gaps:	66/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLA 134
            ||.::...::||||.:||.:...::....::|......|.:..:||.|           :|
Zfish     1 MDLEEAFQVVGEFGSHQKRMITVLVFLQIYMACQSMLIILVGAVPEYH-----------IE---- 50

  Fly   135 LSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWVCD 199
               |:|.|                ..|.|..             |..||| ...::.||...|..
Zfish    51 ---PVTEG----------------VDGDVTQ-------------SVKFTE-DVNSIVTEWYLVKH 82

  Fly   200 DAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRFF 264
            .|.....|.|:||.|.::|.::||.::|:.||.|..:......:|.|.|||...::..||:.|..
Zfish    83 QAYKVNLAGSLFFAGVLIGNVVFGPLSDKIGRKPVFLTGLFFEVLFGYGTALAPSYEAFAVSRLL 147

  Fly   265 VGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSAPL 329
            ||........:.::|..||||..|......::...|..|.: |...:.|::..|:.||...:.|.
Zfish   148 VGVMNGGMALVCFVLTQEYVGKSYWAMTGTLTNMTFAVGIS-LFAALGYYVRPWRNLATAANCPG 211

  Fly   330 LLAIFTPFVVPESARWLVSQGKVDKAVGILK--KLEKGNGRQVPPQTYQIFTDSCKRMQEQEAQN 392
            ||.......:|||.|||.|:|..:||..||:  .|..|.||.|..          .|.......:
Zfish   212 LLLFLLCVTLPESPRWLYSRGYTEKAEDILQDFALRNGKGRIVVK----------LRRASSSPNS 266

  Fly   393 GKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPADTLLT 457
            ....|..|...|.||..|::|:.:|.|.|||:.|...|.|....:.:.:..:....||||..|..
Zfish   267 SSPGVFQLVTHPVLRWRTVVLMYVWYACSLVYYGLTLNAGEDKGNRYLSVAMYGLVELPAYPLCM 331

  Fly   458 VILDR--FGRRWLACSSMVLSGVFSLLATVVPVG---IYSAALAIMGRFFVNISYNIGLQWAAEV 517
            ..:::  .|||....:.:..:|:..||..||||.   :.:.:||::|:..|:.::||...:.:|:
Zfish   332 YFINKPWAGRRKSMANFLAFAGISCLLTMVVPVSGSLLSATSLALVGKLMVSAAFNIVYVYTSEL 396

  Fly   518 LPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPETLNHVLP 582
            .|||:|...:....:...|..|:||||..:.::..::|.::..:.||..|.|.||||||||....
Zfish   397 YPTVIRNAGLGVCSMSCRVGGILAPFVPSMKSLHTSMPFMVFCLSGISAGCLGLLLPETLNKPAA 461

  Fly   583 QTLSD 587
            :||.:
Zfish   462 ETLDE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	128/478 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	102/345 (30%)
slc22a15	NP_001103169.1	2A0119	11..463	CDD:273328	141/510 (28%)
slc22a15	NP_001103169.1	MFS	87..453	CDD:119392	110/376 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850