DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and CG16727

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	204/568 - (35%)
Similarity:	313/568 - (55%)	Gaps:	49/568 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSF---FVAFVYFSQIFLTLIPEQHWCHVPELDGLD-VE 130
            ||||.:|...|.|||:|   |:.:|.:.:   ..:..||||..:|..|| |||...:|.||. .|
  Fly     1 MDFDRVLEKCGNFGRFQ---FVILILYGYTNILSSLHYFSQTLITFTPE-HWCSHDDLMGLGAAE 61

  Fly   131 ARLALSIPMTNGEYNNCYMYD--VNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATE 193
            .|...|    |..:.:|.:..  :|.|.:.:           :..|: .|.:. .|..|.::.||
  Fly    62 LRSIYS----NVSHPSCTLLSEVINGTGVAS-----------EESCQ-DWIFE-RENGYESLTTE 109

  Fly   194 QNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNF--- 255
            ..||||.:..|...||.||||::||.:.||:::|..||:||:    :|..|:|....|:::|
  Fly   110 LKWVCDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPAM----LMAALSGATGDFITSFVHT 170

  Fly   256 --WEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADW 318
              | ||..||..|.:.|..:.:|||||.||:.||.|||..|:.:|:|:.......||||.::.:|
  Fly   171 LPW-FAFSRFVSGLSTDTMYYLMYILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNW 234

  Fly   319 KLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCK 383
            :....:.|.|.|..:..|.::.|||:||:::.|.|:||..|||:.|.|||||....:..|....:
  Fly   235 RRYLWLASLPALGVLIYPLLICESAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEFVKHYR 299

  Fly   384 RMQEQEAQNGKY--SVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLAC 446
            ....:|::..|.  :.|.:||:|||||.|..|:|..:.|:|.:|...||:..||...|..|:|..
  Fly   300 EKMNEESKLNKQMDTFLGMFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFSLTS 364

  Fly   447 FTELPADTLLTVILDRFGRRWLACSSM----VLSGVFSLLATVVPVGIYSAALAIM---GRFFVN 504
            ...|||...:.::.::.||:.:||.::    :::.|...|..|:.....:..||:|   |||...
  Fly   365 SVYLPAGFTILLLQNKIGRKGMACGALLVGAIITAVTGFLIAVLDPSENAVLLALMVGLGRFGTT 429

  Fly   505 ISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLL 569
            :||:..:|:|||::||.||.|||:.||::|..:|.:|.:|:|||...:.||.|.:.:|..:|.||
  Fly   430 VSYDAEIQYAAEIIPTSVRGQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISVLMFLGALL 494

  Fly   570 ALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQ---VDDDEDEK 614
            .|.|||||:..||:||:|||.|...:|...||||.|:   :.:.||.|
  Fly   495 CLTLPETLHKKLPETLADGERFAMNESCLYFPCLHKRRESLTEHEDRK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	169/491 (34%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	127/352 (36%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	184/523 (35%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	138/378 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471419
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.010