DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and slc22a2

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	581	Identity:	173/581 - (29%)
Similarity:	295/581 - (50%)	Gaps:	52/581 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 FDDILPLIGEFGRYQKLLF--ICM--IPFSFFVAFVYFSQIFLTLIPEQHWCHVP------ELDG 126
            |::||...|.|||.|..:|  .|:  ||||    |||...:|....|| |||..|      |..|
Zfish     4 FEEILEEAGTFGRSQIRIFCTFCLVSIPFS----FVYVGIVFQGFTPE-HWCRDPGVSEIRERCG 63

  Fly   127 LDVEARLALSIPMTNG----EYNNCYMYDVNYTDILAQGKVMADPK----------WPQVKCRHG 177
            ..::.....::|:.||    .|:.|..:||::.   |.|....:|.          .|.:.|..|
Zfish    64 WSLQDARRATVPLINGSSGASYSQCGRFDVDWN---ATGLSCENPDGDFNQSQLSVMPMMSCVDG 125

  Fly   178 WSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMG 242
            |.|::  :...:..||.:.||.||......|:...:|.:||.:..|::||::||:.:.:.||...
Zfish   126 WEYDY--VGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNFFI 188

  Fly   243 LLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACL 307
            .:.|:..|...|:....:.|...||.....:.:.|:|:.|.||..:|..| .::..:||:....|
Zfish   189 GVTGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTV-GVTYQLFFSMGILL 252

  Fly   308 LPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPP 372
            ||.:|||:.:|:.|.:|.:.|.:..:...:.:|||.|||::|.|:.:||.|.|.:.|.|.:.:
Zfish   253 LPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTL-- 315

  Fly   373 QTYQIFTDSCKRMQEQEAQNGK-YSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGL 436
                  :...:.:::....:|. .|.:||||:.:||..|.:|...|...::|:.|.:..:|.||.
Zfish   316 ------SKKIETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGG 374

  Fly   437 DIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--SAALAIMG 499
            :::..|.::...||||..|:.:.::|.|||....::.:::|...|:...:|..::  .:|:|.:|
Zfish   375 NVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDSMFWLKSAVACVG 439

  Fly   500 RFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILG 563
            |..:.:::.:.:....|:.|||:|...|:....:..|..|:|||::| ||.|...|||||.|.|.
Zfish   440 RLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALA 504

  Fly   564 IIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDD--DEDEKRNADVEEV 622
            .:.|.|.||||||....||:|:.|.|...|.:   :.|..::|:::  ..|..:|.||..|
Zfish   505 FVAGGLVLLLPETKGVPLPETIDDIEHPNRNK---ENPQQSQQLENLMTSDVTKNKDVTAV 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	142/499 (28%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	94/341 (28%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	159/531 (30%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	111/377 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850