Protein Alignment CG42269 and SLC22A25

DIOPT Version :9

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: XP_016873173.1
• Gene: SLC22A25 / 387601
• HGNCID: 32935
• Length: 577
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 146/601 - (24%)
• Similarity: 248/601 - (41%)
• Gaps: 115/601 - (19%)

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSF----------FVAFVYFSQIFLTLIPEQHWCH---- 120
            |.|.|:|..:|..||:|.|..:.:|.|:.          |.||:         :..:.|.|
Human     1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFI---------LDHRCWVHILDN 56

  Fly   121 --VPELD--GLDVEARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKWPQV-------- 172
              :|:.|  .|..:|.|.:|||. :|.....|..:              ..|:|..:
Human    57 DTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRF--------------VHPQWKLIHLNGTFPN 107

  Fly   173 -------KCRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADR-- 228
                   .|..||.|:.:..| :|:.|:.:.||:...|.:.|:.:|..|.:|||.|:|.::||
Human   108 TSEPDTEPCVDGWVYDQSSFP-STIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKP 171

  Fly   229 ----------------------------FGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRFFV 265
                                        |||...|..:.:...:.|...||......:..:||..
Human   172 LSSPNHVSTDCDEGLEVPIAIHQHHVFWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLA 236

  Fly   266 GFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSAPLL 330
            |.|..:......:|::|::..::......:::.....| ...|..:|:.:.|..:|.:|.|||..
Human   237 GAATFSIIVNTVLLIVEWITHQFCAMALTLTLCAASIG-HITLGSLAFVIRDQCILQLVMSAPCF 300

  Fly   331 LAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQ--TYQIFTDSCKRMQEQEAQNG 393
            :.......:.||||||:...|.::.:..|:|....||.:....  |.::...:.|  ||.||...
Human   301 VFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMK--QELEAAQK 363

  Fly   394 KYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPADTLLTV 458
            |:|:.:|.:.|.:.:....|..:..|.::.|.|...::..||.::|...||.....|.|:.:...
Human   364 KHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPW 428

  Fly   459 ILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--------SAALAIMGRFFVNISYNIGLQWAA 515
            .|:...||   .|.|:|   ..||||.:...|:        ...||.:|....::..........
Human   429 ALNHMSRR---LSQMLL---MFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQEN 487

  Fly   516 EVLPTVVRAQAVA----FIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPET 576
            |::|:::|.:|..    |.:|.|.:||::....:|    |:.||.||.|:..|:.||:.||||||
Human   488 ELIPSIIRGRATGITGNFANIGGALASLMMILSIY----SRPLPWIIYGVFAILSGLVVLLLPET 548

  Fly   577 LNHVLPQTLSDGEEFG 592
            .|..|..::.|.|..|
Human   549 RNQPLLDSIQDVENEG 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	122/549 (22%)
		MFS	206..545	CDD:119392	87/382 (23%)
SLC22A25	XP_016873173.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940