DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and CG10486

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	286/615 - (46%)
Similarity:	385/615 - (62%)	Gaps:	22/615 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GF---KKGQEMAGGNGSDSLPPSMDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLT 111
            ||   ||..|.:....|......:||||:||:||:|||:|..||:.||||.|..||||..|||:.
  Fly    71 GFFWGKKKSETSLPRRSWETDDYIDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMC 135

  Fly   112 LIPEQHWCHVPELDGLDVEARLALSIPM-TNGEYNNCYMYDVNYTDI-LAQG-KVMADPKWPQVK 173
            |.|.:::|:||||....||.|..||||. .:|.|:.|.||:.|||.| .|:. ....:...|.:.
  Fly   136 LTPPKYYCYVPELLHTPVELRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIP 200

  Fly   174 CRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGT 238
            |:.|:.:......:.:...|..|:|||....||||.|||||:|:|||.:|..||..||:.||:.:
  Fly   201 CKKGYVFEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSS 265

  Fly   239 NMMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTG 303
            ..:.|:..:.|:..::|:.|||.||.||.::|.||||:||||||||||||||.|||:|:|:|::.
  Fly   266 CFLALVGSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSP 330

  Fly   304 AACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGR 368
            ...::||||....:|:..:..||.|::||:|:..::|||||||||.|::|||:.|||.:.:.|.:
  Fly   331 FTMVMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKK 395

  Fly   369 QVPPQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGS 433
            ||..:...:|..||.:..::|.....::||.:||..|:.|..:|:|:|||:||||:|||||....
  Fly   396 QVSKEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASV 460

  Fly   434 LGLD-IFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYSAALAI 497
            |..: ||..||:||.||||.:.|:.:.|||.||||.:.....||||||||.............|:
  Fly   461 LDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASFQNRANMRMSAL 525

  Fly   498 MGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGIL 562
            .||||.||.||||||||||:||||||||.|||||.||:||.:::|.||||:..|.:..||:||.|
  Fly   526 AGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGAL 590

  Fly   563 GIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEVRSQAF 627
            ||.||||||.|||||||.||:|||||.:||:.|.||..||...  ...:...|:
  Fly   591 GIFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGP--GSRKSHPRH----------- 642

  Fly   628 VRGTQTGASLNASTGGELRSSILRRSTKSR 657
              ....|:||...:..|.|||.:.|.||.|
  Fly   643 --NWHQGSSLRTLSKDEFRSSKMYRKTKYR 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	226/475 (48%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	170/339 (50%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	249/507 (49%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	189/370 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471394
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	10	9.910