DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	605	Identity:	156/605 - (25%)
Similarity:	270/605 - (44%)	Gaps:	73/605 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 FDDILPLIGEFGRYQ-KLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPEL----DGLDVEA 131
            |..::..|||||.:| :|:.:..|| |....|..||..|| |..::.:|:...:    ..|..:.
Mouse    51 FASVMDAIGEFGTFQWRLVVLTFIP-SILSTFFIFSHHFL-LTAQRPYCNTSWILEVGPNLTEDE 113

  Fly   132 RLALSIPMT-NGEYNNCYMY-------------DVNYTDILAQGKVMADPKWPQVKCRHGWSYNF 182
            :|.|::|.. ||.:..|.||             .:|||:                .|:.||.|.|
Mouse   114 QLNLTLPRAPNGSFLTCLMYIPVPWDLDSIIHFGLNYTE----------------TCKFGWIYPF 162

  Fly   183 TEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGV 247
            ...  .::..|.:.||.:........::|..|.:.|.||||:::|:.||.|.::.:.:..|:.|.
Mouse   163 AHT--RSLINEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLLGFLIFGF 225

  Fly   248 GTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIA 312
            ||||||:|:::...||||..|..........||:|::..::|.....:..: |.|....||..:|
Mouse   226 GTAFVSSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAVILQHS-FLTIGVILLTGLA 289

  Fly   313 YFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQI 377
            |.:..|:||.::...|:...|...:|:.||.|||:.:|||::|..:|....:.|.:.:|......
Mouse   290 YKVVHWRLLCLLGGMPMFPLICNIWVLRESPRWLMVRGKVEEAKKVLCYAAEVNKKTIPLNLLNE 354

  Fly   378 FTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTF 442
            ...|.|::       .|.|:||...:..|.:..|.:..:|..:|.:.......:...|||::|..
Mouse   355 LQISGKKV-------AKASILDFCTNQHLFKVVLAIGCVWFTVSYISFTLNLKMNDFGLDVYFVQ 412

  Fly   443 TLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYSAAL--AIMGRFFVNI 505
            .:.....:||.....::|:.|||:|....::.|.....|....:|....|..:  .::..|.:..
Mouse   413 MVRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMCLFLLFLPQEPKSTIILTLMLAEFSMAG 477

  Fly   506 SYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLA 570
            :.:|...:.||:||||:|:..:..:. :.:||..|:...::....:| ||:....:..::....:
Mouse   478 TLSIFFIYTAELLPTVLRSTGLGMVS-LAWVAGAISSVAIFKQTKTQ-LPIFFCCLCCVLALCFS 540

  Fly   571 LLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADV-----EEVRSQAFVRG 630
            .|:|||.:    |:|.|..|:....||             |.:.||.||     ||..|......
Mouse   541 SLVPETGS----QSLRDSIEYNIRDSI-------------EPKDRNKDVPMVIAEESMSDIVADS 588

  Fly   631 TQTGASLNASTGGELRSSIL 650
            ..|..:|||.|.....:|:|
Mouse   589 EVTNTTLNAVTFKPEENSLL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	126/492 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	90/340 (26%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	135/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844090
Domainoid	1	1.000	69	1.000	Domainoid score	I9569
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840