DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001119757.1	Gene:	Slc22a13 / 316062	RGDID:	1306840	Length:	551	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	188/572 - (32%)
Similarity:	300/572 - (52%)	Gaps:	40/572 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 FDDILPLIGEFGRYQKLLFICM-IPFSFFVAFVYFSQIFLTLIPEQHWCHVPELD----GLDVEA 131
            |..::..:|:|||:|..|.|.| || :|..||..|||:|:.| .|.|:|.|..:.    .|....
  Rat     4 FAQVMAEVGDFGRFQVRLTILMGIP-NFLSAFFVFSQVFMVL-DEAHYCSVSWVKNHTFNLSAAE 66

  Fly   132 RLALSIPM-TNGEYNNCYMY-----DVNYTDILAQGKVMADPKWPQVK-CRHGWSYNFTEIPYAT 189
            :||:|||. |.|...:|.|:     :.:..|||:.       ::.:.: |..||.|.....|  :
  Rat    67 QLAVSIPNDTAGRPESCLMFRPPPDNASLEDILSH-------RFNETQACDSGWDYPENRPP--S 122

  Fly   190 VATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSN 254
            :..|.:.||:...|...:||:|..|.:||.|:||.|.|..||.|:|:...::..:|.:.|||||:
  Rat   123 LKNEFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQLLLSGIASMATAFVSS 187

  Fly   255 FWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWK 319
            |..:..:||.:..|.........:|:.|:||...||....::.:.|..|... |..:||.:.:|:
  Rat   188 FELYMTLRFALATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSNFALGLMA-LAGLAYGVRNWR 251

  Fly   320 LLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKR 384
            ||.|:.:.|:.|.:|..:|:|||.|||:|||:.::|..:::|....|||.:..:...      :.
  Rat   252 LLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASELLN------QL 310

  Fly   385 MQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTE 449
            :.|:...:|  :.||||:.|:||:.||:||.:|...||::.|....||..||||:.|..:....|
  Rat   311 VPEKTGPSG--NALDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVIFGVVE 373

  Fly   450 LPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVP--VGIYSAALAIMGRFFVNISYNIGLQ 512
            :||......::::.||:|....::.|:||..::...:|  :...:.|||::|:|..:.::.|...
  Rat   374 VPARLSSIPMMEKLGRKWSQLCTLTLAGVMCVIIIFIPGDLPTVATALAVVGKFASSAAFTISYV 438

  Fly   513 WAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPETL 577
            :.||:|||::|...:..:.|...|..||.|.|:.|....:|:|::|.|.|.|..|||..|||||.
  Rat   439 YTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCALLPETR 503

  Fly   578 NHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKR--NADVEEVRSQAF 627
            ...|..||.|.|:   ||....:. .|.|..|.|...|  :|.|..|||..|
  Rat   504 GQTLKDTLQDLEQ---GQPPRSYK-TAPQRKDVEASGRTSSARVAVVRSSYF 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	155/485 (32%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	109/340 (32%)
Slc22a13	NP_001119757.1	2A0119	12..510	CDD:273328	170/517 (33%)
Slc22a13	NP_001119757.1	MFS	139..500	CDD:119392	121/369 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347204
Domainoid	1	1.000	69	1.000	Domainoid score	I9372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950