DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	157/579 - (27%)
Similarity:	271/579 - (46%)	Gaps:	79/579 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 FDDILPLIGEFGRYQ-KLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPEL----DGLDVEA 131
            |..:|..|||||.:| :|:.:..|| |....|...|..|| |..::.:|:...:    ..|..:.
  Rat    51 FASVLGAIGEFGTFQWRLVALTFIP-SILSTFFLLSHHFL-LTAQRPYCNTSWILQVGPNLTEDE 113

  Fly   132 RLALSIPMT-NGEYNNCYMY-------------DVNYTDILAQGKVMADPKWPQVKCRHGWSYNF 182
            :|.|::|.. ||.:..|.||             .:|||:                .|:|||.|.|
  Rat   114 QLNLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTE----------------TCKHGWIYPF 162

  Fly   183 TEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLA-G 246
            ...  .::..|.:.||.:.......|::|..|.:.|.||||:::|:.||.|.:: .:::|:|. |
  Rat   163 AHT--RSLTNEFDLVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIIL-LSLLGILIFG 224

  Fly   247 VGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAI---FFTGAACLL 308
            .|||||::|:::...||||..|..........||:|::..::|.    .:|.:   |||....||
  Rat   225 FGTAFVNSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRA----QAIILQHCFFTIGVILL 285

  Fly   309 PWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQ 373
            ...||.:..|:||.::...|:...|...:|:.||.|||:.:|||::|..:|....:.|.:.:|
  Rat   286 TGFAYKINHWRLLFLLGGVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNKKTIP-- 348

  Fly   374 TYQIFTDSCKRMQEQE--AQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGL 436
                    ...:.|.:  .:..|.|:||.:.:..|.:..|.:..:|..:|.|.......:...||
  Rat   349 --------LNLLNELQLPGKKAKASILDFYTNQHLFKVVLAMGCVWFTVSYVSLTLSLKMKDFGL 405

  Fly   437 DIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGV-FSLLATV-VPVGIYSAA--LAI 497
            ||:|...:.|.|.:||.....::|:.|||:|  ..::.||.| |:.|:.: ||..:.|..  :.:
  Rat   406 DIYFIQVVPCITAVPARLCCILLLEYFGRKW--SLNLTLSLVTFTCLSLLFVPEELKSTTILMLV 468

  Fly   498 MGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGIL 562
            :|.|.:..:.:|...:.||:|||::|:..:..:.| .:.|..|:...::....:| ||:....:.
  Rat   469 LGEFSMAGTVSIFFIYTAELLPTILRSTGLGMVSI-AWTAGAISSLAIFKQTKTQ-LPIFFCCLC 531

  Fly   563 GIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEE 621
            .|:....:.|:|||.|    |.|.|..|:....|:       :..|..:|..:....||
  Rat   532 CILALCFSSLVPETGN----QPLRDSIEYCSRDSL-------EHKDKSKDSSKVLMAEE 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	136/500 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	100/348 (29%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	115/416 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010