DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	161/532 - (30%)
Similarity:	264/532 - (49%)	Gaps:	30/532 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLAL 135
            |:|::...:||:|.:|:|:|..:........|...|.:||...|| |.|.||....|. .|....
  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPE-HRCLVPHTVNLS-SAWRNH 65

  Fly   136 SIPMTNGE----YNNCYMYDV----NYTDI-LAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVA 191
            |||:...:    ..:|..|.:    |::.: |..|:.:...:..|..|..||.|| .::..:|:.
  Rat    66 SIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYN-KDVFLSTIV 129

  Fly   192 TEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVG--TAFVSN 254
            ||.:.||.|........|:||:|.::|..:.|.::|||||...|..|  ||:..|..  ..|..|
  Rat   130 TEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLT--MGMQTGFSFLQLFSVN 192

  Fly   255 FWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWK 319
            |..|.::...||....:.:...::|..|.:....|...|.:.:.||:.....:||..|||:.||:
  Rat   193 FEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWR 257

  Fly   320 LLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKR 384
            :|.:..:.|.:|.....:.:|||.|||:|||:|.:|..|::|..|.|| .|.|.|  ||..|
  Rat   258 MLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNG-IVAPST--IFDPS--- 316

  Fly   385 MQEQEAQNGK----YSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLA 445
              |.:..|.|    :.:.||.::..:|..|::.|::|:.||:.:.|...:..:|..||:....|.
  Rat   317 --ELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLL 379

  Fly   446 CFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--SAALAIMGRFFVNISYN 508
            ...|:||..|..::|....||:...:::.|.|...|...:||..::  |.||.::|:|.:..:|:
  Rat   380 AAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYS 444

  Fly   509 IGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLL 573
            :...:.||:.|||||...|........:.||::|:.|||....:.||.|::|.|.|:..:|.|..
  Rat   445 MVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFF 509

  Fly   574 PETLNHVLPQTL 585
            ||:....||.|:
  Rat   510 PESFGAPLPDTI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	146/488 (30%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	105/346 (30%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	158/520 (30%)
		MFS	123..510	CDD:119392	122/396 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850