DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Sv2c

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	129/668 - (19%)
Similarity:	215/668 - (32%)	Gaps:	246/668 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 TNGEYNNCYMYDVNYTDILA--QGK----VMADPKWPQVK------------------------- 173
            |.|......:|:..|..|.:  |||    .:..||..:.|
  Rat    79 TEGHDEEDEIYEGEYQGIPSTNQGKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQ 143

  Fly   174 -CRHG---WSYNFT-------------EIPYATVATEQNWVCDDAALPT----YAQSIFFLGAIV 217
             |.||   |:..|.             .:.:...:.|     .|..:|.    :..||.:||.:|
  Rat   144 ECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE-----TDLCIPNSGSGWLGSIVYLGMMV 203

  Fly   218 GGLLFGWVADRFGRIPA-LIGTNMMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVL 281
            |...:|.:||:.||..: ||..::.|..|.: ::||..:..|.:.|...||........::....
  Rat   204 GAFFWGGLADKVGRKQSLLICMSVNGFFAFL-SSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFA 267

  Fly   282 EYVGPKYRTFVANMSIAIFFTGA--ACLLPWI-------------AYFLADWKLLAIVTSAPLLL 331
            |.:..:.|....:.....:..|.  |..:.|.             ||....|::..||.:.|.:.
  Rat   268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVS 332

  Fly   332 AIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFT-------DSCKRMQEQE 389
            ::.....:|||.|:|:..||.|:|..|||.:...|.| ...|..::||       .....:.|.|
  Rat   333 SVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMR-ARGQPEKVFTVNKIKTPKQIDELIEIE 396

  Fly   390 AQNGKY-----------------SVLDLFKSPRLRRTTLLLIVIWMAISLVFDG----------H 427
            :..|.:                 :.:..|..| :|..|:.|.::|..:|..:.|          |
  Rat   397 SDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRENTIKLTIVWFTLSFGYYGLSVWFPDVIKH 460

  Fly   428 V---------RNVGS---------------------------LGLD------------------- 437
            :         |||..                           ||:.
  Rat   461 LQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDV 525

  Fly   438 --------------------------------------------------------IFFTFTLAC 446
                                                                    |:|...|..
  Rat   526 TSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGT 590

  Fly   447 FTELPADTLLTVILDRFGRRWLACSSMVLSGV---FSLLATVVPVGIYSAALAIMGRFFVNISYN 508
            ...||.:.:..:::||.||..:...||||||:   |....|...:.|....|           ||
  Rat   591 LAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCL-----------YN 644

  Fly   509 IGLQWAA---------EVLPTVVRAQAVAFIHIMGYVASIIAPFVV-YLANISQALPLIILGILG 563
             ||..:|         |:.||..||....|::.:...|:::...:. .|.:|::|:|:::...:.
  Rat   645 -GLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVL 708

  Fly   564 IIGGLLALLLPETLNHVL 581
            :.|||:.|.||:|...||
  Rat   709 VCGGLVGLRLPDTRTQVL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	118/637 (19%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	97/511 (19%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	129/668 (19%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120		11/40 (28%)
		MFS	155..719	CDD:119392	109/583 (19%)
		Pentapeptide_3	507..561	CDD:290309	0/53 (0%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		0/36 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910