DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	177/546 - (32%)
Similarity:	282/546 - (51%)	Gaps:	37/546 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 FDDILPLIGEFGRYQKLLF--ICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGL------- 127
            ||..|...|||||:|:.:|  :|:...:|  ||::...:||...|:.:||..|....|
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTF--AFLFVGVVFLGSQPDYYWCRGPRATALAERCAWS 66

  Fly   128 -DVEARLA---LSIPMTNGEYNNCYMY---DVNYTDILAQGKVMADP--KWPQVKCRHGWSYNFT 183
             :.|..|.   |.:|.......:|:.|   |.|.:..|:...:.|.|  ..|.|.|...|.|..|
  Rat    67 PEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVET 131

  Fly   184 EIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGR-IPALIGTNMMGLLAGV 247
               ::|:.::.:.||.:|.:....|:|..||.:.|....|:.|||:|| |..||....:| :.||
  Rat   132 ---HSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVG-ITGV 192

  Fly   248 GTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIA 312
            ..||..||..|.|.||..|......:...:::|.|.||.|.|..| .:.|.:|||....:||.||
  Rat   193 VVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIV-GIVIQMFFTLGIIILPGIA 256

  Fly   313 YFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQI 377
            ||...|:.:.:..|.|..|.:...:|||||.|||:::.:.:||:.||:::.|.||:.:.....:|
  Rat   257 YFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEI 321

  Fly   378 FTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTF 442
                  .:.::|..|.  |.|||.::|::|:.||:|:..|...::|:.|.|..:|.:|.:::..|
  Rat   322 ------TVTDEEVSNP--SCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDF 378

  Fly   443 TLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGI--YSAALAIMGRFFVNI 505
            .::...|||...|:.:.::|.|||....:|.:::||..|:...:|.||  ....:|.:||..:.:
  Rat   379 FISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITM 443

  Fly   506 SYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILGIIGGLL 569
            ::.|.....:|:.||.:|...|:....:.....|||||::: ||.|...|||||.|||..:.|.|
  Rat   444 AFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGL 508

  Fly   570 ALLLPETLNHVLPQTLSDGEEFGRGQ 595
            .:|||||....||:|:.|.|:.|..|
  Rat   509 VMLLPETKGIALPETVEDVEKLGSSQ 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	152/493 (31%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	110/341 (32%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	169/525 (32%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	125/377 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850