DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	585	Identity:	160/585 - (27%)
Similarity:	269/585 - (45%)	Gaps:	74/585 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFL---TLIPEQHWCHVPELDG----- 126
            |.||.:|..:|..||:|    ||:|.|......:.|..|.|   |.....|.|.||.||.
Human     1 MGFDVLLDQVGGMGRFQ----ICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSD 61

  Fly   127 -----LDVEARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVK-CRHGWSYNFTE 184
                 |..:..|.:|||: :|.....|..:......:|.......:...|..: |..||.|:.:.
Human    62 NDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRSS 126

  Fly   185 IPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGR--IPALIGTNMMGLLAGV 247
            . .:|:.||.:.||:..:|.:..||:|..|:::|||::|.::||.||  |..|....:  .::..
Human   127 F-LSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQL--AISNT 188

  Fly   248 GTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIA 312
            ..||...|..:.|:||..||:........:||.||:..|:.|:....:.:..:..| ..||..:|
Human   189 CAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVG-QMLLGGLA 252

  Fly   313 YFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTY-- 375
            :.:.||.:|.:..|.|:::...:.:.:.||||||:...::|:.:..|:::...||::...:|.
Human   253 FAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTT 317

  Fly   376 QIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFF 440
            ::...:.|:  |.:|...|.|:..||::|:||.....|..:..||::.|.|.:.|:..||.::..
Human   318 ELVRSTMKK--ELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSL 380

  Fly   441 --------TFTLACFTELPADTLLTVILDRFGRRWLACSSMVL----SGVFSLLATVVP--VGIY 491
                    |||..|.      :|||  |:..|||    .|.:|    .|:|.|:.|.:|  :.|.
Human   381 FQILCGAVTFTARCV------SLLT--LNHMGRR----ISQILFTFPVGLFILVNTFLPQEMQIL 433

  Fly   492 SAALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPL 556
            ...||.:|...|:.:.|.......|::||::|:.......:.|...:.:||.::.|...|..||.
Human   434 RVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPW 498

  Fly   557 IILGILGIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEE 621
            |..|:..|:...:.||||||.:..||.|:.|                   |::|..:.||...|:
Human   499 ISYGVFPILAVPVILLLPETRDLPLPNTIQD-------------------VENDRKDSRNIKQED 544

Fly 622 621
Human 545 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	135/504 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	97/356 (27%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	117/424 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153837
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950