Protein Alignment CG42269 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_036829.1
• Gene: Slc22a1 / 24904
• RGDID: 3224
• Length: 556
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 168/550 - (30%)
• Similarity: 275/550 - (50%)
• Gaps: 43/550 - (7%)

  Fly    73 DDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVP---ELD---GLDVEA 131
            ||:|..:||||.:||..|:.:...|..:|.:|...:||...| .|:|..|   ||.   |.....
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTP-GHYCQNPGVAELSQRCGWSQAE 68

  Fly   132 RLALSIPMTNGE-----YNNCYMYDVNYTDILAQGKVMADP---------KWPQVKCRHGWSYNF 182
            .|..::|.....     .:.|..|:|::......   ..||         :.|...|.|||.|
  Rat    69 ELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLD---CVDPLSSLVANRSQLPLGPCEHGWVY-- 128

  Fly   183 TEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGV 247
             :.|.:::.||.|.||.||......||...||..:|.|:.|::||||||...|:.|.::..::||
  Rat   129 -DTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGV 192

  Fly   248 GTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVA---NMSIAIFFTGAACLLP 309
            .||...::....:.|...|......:...|.|:.|:||..||...|   .|:..:...|    |.
  Rat   193 LTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVG----LA 253

  Fly   310 WIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQT 374
            .:||.:.||:.|.:..|.|..|.:...:.||||.|||:||.:..:||.|::::.:.||: |||..
  Rat   254 GVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGK-VPPAD 317

  Fly   375 YQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIF 439
            .::.   |  ::|..::....|..|||::|.||:.|::|:.:|.:.::::.|.:.:||:.|.:::
  Rat   318 LKML---C--LEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLY 377

  Fly   440 FTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--SAALAIMGRFF 502
            ..|..:...|.||..::.|.:||.||.:...:|.:::|...||...:|..::  :..||.:||..
  Rat   378 LDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMG 442

  Fly   503 VNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILGIIG 566
            ..|...:.....||:.||.:|...:.....:..:..|..||:|: |..:.||||||:.|:||:..
  Rat   443 ATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTA 507

  Fly   567 GLLALLLPETLNHVLPQTLSDGEEFGRGQS 596
            |.:.||||||....||:|:.:.|..||.:|
  Rat   508 GAMTLLLPETKGVALPETIEEAENLGRRKS 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	142/497 (29%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	160/529 (30%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)