DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	168/550 - (30%)
Similarity:	275/550 - (50%)	Gaps:	43/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVP---ELD---GLDVEA 131
            ||:|..:||||.:||..|:.:...|..:|.:|...:||...| .|:|..|   ||.   |.....
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTP-GHYCQNPGVAELSQRCGWSQAE 68

  Fly   132 RLALSIPMTNGE-----YNNCYMYDVNYTDILAQGKVMADP---------KWPQVKCRHGWSYNF 182
            .|..::|.....     .:.|..|:|::......   ..||         :.|...|.|||.|
  Rat    69 ELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLD---CVDPLSSLVANRSQLPLGPCEHGWVY-- 128

  Fly   183 TEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGV 247
             :.|.:::.||.|.||.||......||...||..:|.|:.|::||||||...|:.|.::..::||
  Rat   129 -DTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGV 192

  Fly   248 GTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVA---NMSIAIFFTGAACLLP 309
            .||...::....:.|...|......:...|.|:.|:||..||...|   .|:..:...|    |.
  Rat   193 LTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVG----LA 253

  Fly   310 WIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQT 374
            .:||.:.||:.|.:..|.|..|.:...:.||||.|||:||.:..:||.|::::.:.||: |||..
  Rat   254 GVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGK-VPPAD 317

  Fly   375 YQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIF 439
            .::.   |  ::|..::....|..|||::|.||:.|::|:.:|.:.::::.|.:.:||:.|.:::
  Rat   318 LKML---C--LEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLY 377

  Fly   440 FTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--SAALAIMGRFF 502
            ..|..:...|.||..::.|.:||.||.:...:|.:::|...||...:|..::  :..||.:||..
  Rat   378 LDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMG 442

  Fly   503 VNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILGIIG 566
            ..|...:.....||:.||.:|...:.....:..:..|..||:|: |..:.||||||:.|:||:..
  Rat   443 ATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTA 507

  Fly   567 GLLALLLPETLNHVLPQTLSDGEEFGRGQS 596
            |.:.||||||....||:|:.:.|..||.:|
  Rat   508 GAMTLLLPETKGVALPETIEEAENLGRRKS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	142/497 (29%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	100/343 (29%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	160/529 (30%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	125/402 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850