DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	556	Identity:	161/556 - (28%)
Similarity:	255/556 - (45%)	Gaps:	60/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKL----LFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDG---- 126
            |.|.|:|.|:|..||:|.|    |.||.:   ..:..|.........:..:.|.|:.:.|.
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLICNV---ITMPHVILENFTAANLGHRCWVHIIDNDTNSNN 62

  Fly   127 ----LDVEARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKW--------------PQV 172
                |..:..|.:|||: :|.....|..:              ..|:|              |..
Mouse    63 NSGILSQDDLLRISIPLDSNLRPEKCRRF--------------VQPQWHLLQFNGSFSNMTEPDT 113

  Fly   173 K-CRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALI 236
            : |..||.|:.... .:|..||.|.||....|.:.|:.||.:|.:.|..:.|.::|:|||.....
Mouse   114 EPCMDGWVYDQRTF-LSTTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFR 177

  Fly   237 GTNMMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFF 301
            ...:...:.|..||....|:.:.::||..|.......|...:|:||:..||.:..|..:|::...
Mouse   178 CALLQMAITGTCTALAPTFFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPKTQALVTTLSMSSHH 242

  Fly   302 TGAACLLPWIAYFLADWKLLAIVTSAPL-LLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKG 365
            .| ..:|..:|:...:|..|.:..|.|: :|.|.|...:.||||||:...|..||:..|:|:...
Mouse   243 FG-GLILAGLAFAFQNWHHLQLAISVPIFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASK 306

  Fly   366 NGRQVPPQTYQIFTDSCKR--MQEQEA-QNGKYSVLDLFKSPRLR-RTTLLLIVIWMAISLVFDG 426
            ||.:   .:..:.|....|  |:::.| ...|.|:.|||..|.|| |..||.::.::.||... |
Mouse   307 NGIK---NSEDVLTMEVVRTIMKDEIAIPRTKPSLRDLFHMPNLRKRLCLLCLLRFLQISPTV-G 367

  Fly   427 HVRNVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY 491
            ...|:..|..::|.|.:|.....:||..|...:|:..|||.......:|.|:|.|....||..:.
Mouse   368 INMNLQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFLLSIVSVPQEMQ 432

  Fly   492 S---AALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQA 553
            :   ..:.:.|.....| ||..:.:::|::|||:||.|:..|.|.|.|.:.::|.::.|...|.:
Mouse   433 TLLVVLITLAGGSSAMI-YNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSAS 496

  Fly   554 LPLIILGILGIIGGLLALLLPETLNHVLPQTLSDGE 589
            ||.||.|:|.|:||||.|:||||.|..||.::.|.|
Mouse   497 LPWIIYGVLSILGGLLPLILPETKNQPLPDSIQDVE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	134/507 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	100/346 (29%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	119/403 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940