DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	556	Identity:	162/556 - (29%)
Similarity:	251/556 - (45%)	Gaps:	61/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDG-------- 126
            |.|.|::..||..||:|.|..|.::......|.....:.|...|| .|.|.||.||.
Mouse     1 MAFQDLIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIP-SHRCWVPILDNDTASDNGS 64

  Fly   127 --LDVEARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKW---------PQV------K 173
              |..:..|.:|||: :|...:.|..|              ..|:|         |.|      .
Mouse    65 RILSQDDLLRISIPLDSNLRPDKCRRY--------------IQPQWHLLHLNGTFPTVTEPDTEP 115

  Fly   174 CRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGT 238
            |..||.|:.:.. .:|..|:.:.||...||.:.|:.|:..|..:|.::.|.::|:|||  .||.|
Mouse   116 CVDGWVYDQSTF-LSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGR--KLIFT 177

  Fly   239 NMMGLLAGVGT--AFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFF 301
            ..:..:|...|  ||..:|..:..:||..|.......|...:|:||:..||::..|  |::....
Mouse   178 CSLLKMAITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALV--MALIFIA 240

  Fly   302 TGAA-CLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLE-- 363
            :|.. .||..:|:...:|..|.:..|.|:.|.:.....:.||||||:...|..|::..|||..
Mouse   241 SGVGQTLLGGLAFAFRNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACV 305

  Fly   364 ---KGNGRQVPPQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFD 425
               |.:|..:   |.::.....|  :|.||...|.|.||||::|.||:...||..:.....:...
Mouse   306 NRIKNSGDAL---TLEVVKTIMK--EELEAAQTKPSPLDLFRTPNLRKRICLLSFVRFVSVMSLL 365

  Fly   426 GHVRNVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVP--V 488
            |.:.|:..|..::|....|.....:||:.|....::..|||......|.:.|:..|....:|  :
Mouse   366 GLLINIQYLSNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEM 430

  Fly   489 GIYSAALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQA 553
            .|....|:.:|....:.|....|..|.|::||::||.|:..:.|.|.....::|.::.|...|.:
Mouse   431 QILRVFLSTLGGAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSAS 495

  Fly   554 LPLIILGILGIIGGLLALLLPETLNHVLPQTLSDGE 589
            ||.||.|||..:|||:|||||||.|..||.::.|.|
Mouse   496 LPWIIYGILPFLGGLVALLLPETKNQPLPDSIQDIE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	135/507 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	96/348 (28%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	155/538 (29%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940