DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus

Alignment Length:	544	Identity:	167/544 - (30%)
Similarity:	263/544 - (48%)	Gaps:	37/544 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVP---ELD---GLDVEA 131
            ||||..||||..:||..|..:...|.....:|...:||...|..| |..|   ||.   |.....
Mouse     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPNHH-CRSPGVAELSQRCGWSPAE 68

  Fly   132 RLALSIP--MTNGE---YNNCYMYDVNYTDILAQGKVMADP---------KWPQVKCRHGWSYNF 182
            .|..::|  .:.||   .:.|..|:|::......   ..||         ..|...|.|||.|
Mouse    69 ELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLD---CVDPLSSLAANRSHLPLSPCEHGWVY-- 128

  Fly   183 TEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGV 247
             :.|.:::.||.|.||..:.:....||:..:|..:|.:..|::||||||...|:.|.::..::||
Mouse   129 -DTPGSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINAISGV 192

  Fly   248 GTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIA 312
            ..|...|:....:.||..|......:.:.|||:.|:||..||..| .:...|.||....:|..:|
Mouse   193 LMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTV-GICYQIAFTVGLLILAGVA 256

  Fly   313 YFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQI 377
            |.|.:|:.|....:.|....:...:.:|||.|||:||.|..||:.|:|.:.|.||:.||.....:
Mouse   257 YALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSLQSL 321

  Fly   378 FTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTF 442
            ..|      |........|.|||.::|::|:.||:|:..|...|:::.|.:.::|..|.:|:..|
Mouse   322 TAD------EDTGMKLNPSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDF 380

  Fly   443 TLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGI--YSAALAIMGRFFVNI 505
            ..:...|.||..::.:.:||.|||:....|.:::|...|.:..:|..:  ....:|.:||..:.|
Mouse   381 FYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITVACLGRMGITI 445

  Fly   506 SYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILGIIGGLL 569
            :|.:.....||:.||.:|..||.....|..:..|:.||:|| |.:|....||::..::|::.|.|
Mouse   446 AYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGGL 510

  Fly   570 ALLLPETLNHVLPQTLSDGEEFGR 593
            .||||||....||:|:.|.|:..|
Mouse   511 VLLLPETKGKALPETIEDAEKMQR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	145/494 (29%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	103/340 (30%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	158/526 (30%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	115/376 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850