DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	159/545 - (29%)
Similarity:	260/545 - (47%)	Gaps:	31/545 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELD--------- 125
            |.|.|:|..:|..||:|.|....::.|:..::.....:.|..:|| .|.|.||.||
  Rat     1 MAFQDLLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIP-NHRCWVPILDNDTVSGNDN 64

  Fly   126 -GLDVEARLALSIPMTNG-EYNNCYMYDVNYTDILAQGKVMADPKWPQVK-CRHGWSYNFTEIPY 187
             .|..:..|.:|||:.:. ....|..:.....|:|......:....|..: |..||.|:.:.. .
  Rat    65 GNLSQDDLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVDGWVYDQSTF-L 128

  Fly   188 ATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFV 252
            :|:.||.:.||:..:|.:.|:.:|..|.:||.:|:|.:.|||||...||..::...:.....||.
  Rat   129 STIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAFA 193

  Fly   253 SNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLAD 317
            ..|..:..:||..|.:|....|...:|::|:..||::.....:.:.....|.. :|..:|:.:.:
  Rat   194 PTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQT-VLAGLAFTVRN 257

  Fly   318 WKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSC 382
            |..|.:..|.|:...:.....:.||||||:...|:.|.:..|.|:...||.:.......|.....
  Rat   258 WHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIEVVRT 322

  Fly   383 KRMQEQEAQNGKYSVLDLFKSPRLRRTTLLL----IVIWMAISLVFDGHVRNVGSLGLDIFFTFT 443
            ...:|.||...|.|:.|||::|.||:...||    .|:|:::.    |.:.|...|.:::|....
  Rat   323 IMKEELEASQTKSSLWDLFRTPNLRKRICLLSLVRFVVWLSVI----GLLINFQHLRINVFLLQC 383

  Fly   444 LACFTELPADTLLTVILDRFGRRWLACSSMVLSGVF--SLLATV-VP--VGIYSAALAIMGRFFV 503
            |.....:||:.:...:::..|||   .|.:.:..:|  |:||.: ||  :.|....||..|..|.
  Rat   384 LLGIITIPANLVGIFLVNHLGRR---ISQLFIISLFGISILAIIFVPQEMQILRMVLATFGGVFS 445

  Fly   504 NISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGL 568
            .:|.:..|..|.|:|||::||.|:..|.|.|...:.::|..:.|...|.:||.||.|:|..:|||
  Rat   446 FVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLPWIIYGVLSFLGGL 510

  Fly   569 LALLLPETLNHVLPQTLSDGEEFGR 593
            :.||||||.|..||.::.|.|..||
  Rat   511 VVLLLPETKNQPLPDSIQDVENEGR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	132/492 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	97/347 (28%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	150/523 (29%)
		Aldolase_II	39..>85	CDD:294146	14/46 (30%)
		MFS	125..506	CDD:119392	111/389 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940