DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Sv2a

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_476558.2	Gene:	Sv2a / 117559	RGDID:	619715	Length:	742	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	145/774 - (18%)
Similarity:	241/774 - (31%)	Gaps:	298/774 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YFVNEAFTYEEPPQGGGGGGADALH--------------RRKSGGGNKELQLD-------MGGFK 52
            |:..|....||  :||....|...|              .|...||..|...|       .||..
  Rat    65 YYRGEGAQDEE--EGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLS 127

  Fly    53 KGQEMAGGNG-----SDSLPPSMDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTL 112
            .|:...||.|     .|....:..::.||...|. ||:|..|:           ||    :.|.|
  Rat   128 DGEGPPGGRGEAQRRKDREELAQQYETILRECGH-GRFQWTLY-----------FV----LGLAL 176

  Fly   113 IPEQHWCHVPELDGLDVEARLALSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHG 177
            :          .||::|   ..:...:.:.|.:.| :.|.|      :|.:
  Rat   177 M----------ADGVEV---FVVGFVLPSAEKDMC-LSDSN------KGML-------------- 207

  Fly   178 WSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMG 242
                                          ..|.:||.:||..|:|.:|||.||...|:.:..:.
  Rat   208 ------------------------------GLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVN 242

  Fly   243 LLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYR---------------TFV 292
            .:....::||..:..|...|...|........:::....|::..:.|               .:.
  Rat   243 SVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYA 307

  Fly   293 ANMSIAI-------FFTGAACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQG 350
            |.|:.||       |..|:       ||....|::..:|.:.|.:.||......|||.|:.:..|
  Rat   308 AAMAWAIIPHYGWSFQMGS-------AYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENG 365

  Fly   351 KVDKAVGILKKLE------KGNGRQVPPQTYQIFTDSCKRMQEQEAQNGKY-------------- 395
            |.|:|..:||::.      ||:..:|...|:.........:.|.::..|.:
  Rat   366 KHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQ 430

  Fly   396 ---SVLDLFKSPRLRRTTLLLIVIWMAISLVFDG----------HVRNV----------GSLGLD 437
               :.|..| ||..||.||:::.:|..:|..:.|          |::.|          |.....
  Rat   431 VWGNFLSCF-SPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEH 494

  Fly   438 IFFTFTL-------------------------------ACFTE---------------------- 449
            :.|.|||                               .|:.|
  Rat   495 VTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNT 559

  Fly   450 -------------------------------------------------LPADTLLTVILDRFGR 465
                                                             ||.:.:..:::|:.||
  Rat   560 DLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR 624

  Fly   466 RWLACSSMVLSGVFSLLATVVPVGIYSAALAIMGRFFVNISYNIGLQWAA------EVLPTVVRA 524
            ..:...|.|||.|....   :..|...:|:..:...|..:|.   ..|.|      |:.|:..|.
  Rat   625 LRMLAGSSVLSCVSCFF---LSFGNSESAMIALLCLFGGVSI---ASWNALDVLTVELYPSDKRT 683

  Fly   525 QAVAFIHIMGYVASI--IAPFVVYLANISQALPLIILGILGIIGGLLALLLPETLNHVL 581
            .|..|::.:..:|::  |:.|..:: .|::|.|::.......:|..|||.||||...||
  Rat   684 TAFGFLNALCKLAAVLGISIFTSFV-GITKAAPILFASAALALGSSLALKLPETRGQVL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	111/646 (17%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	93/513 (18%)
Sv2a	NP_476558.2	synapt_SV2	1..742	CDD:130366	145/774 (19%)
		Interaction with SYT1	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..145		19/81 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910