DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	556	Identity:	155/556 - (27%)
Similarity:	274/556 - (49%)	Gaps:	58/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQ-KLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARL 133
            |.|:::|..:|.||.:| :.|.:..:| .|.:...:...||:..:|..| |.:|     |..|.|
Mouse     1 MGFEELLHKVGGFGPFQLRNLVLLALP-RFLLPMHFLLPIFMAAVPAHH-CALP-----DAPANL 58

  Fly   134 A-------LSIPM-TNGEYNNCYMY-------DVNY-TDILAQGKVMADPKWPQVKCRHGWSYNF 182
            :       ..:|. |:|.:::|..:       :|.. |::...|:...:|.  .|.|..||.|:.
Mouse    59 SHQDLWLKTHLPRETDGSFSSCLRFAYPQALPNVTLGTEVYNSGEPEGEPL--TVPCSQGWEYDR 121

  Fly   183 TEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGR----IPALIGTNMMGL 243
            :|.. :|:|||.:.||....|.....:.||:|.::|.:::|:::|||||    :.|.:.|..:||
Mouse   122 SEFS-STIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVSTLALGL 185

  Fly   244 LAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYI-LVLEYVGPKYRTFVANMSIAIFFTGAACL 307
            ::....    |:..|...|...|.|... ||::.: |.||::..::|| ||.:....|:||...|
Mouse   186 MSAASV----NYIMFVTTRMLTGSALAG-FTIIVLPLELEWLDVEHRT-VAGVISTTFWTGGVLL 244

  Fly   308 LPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPP 372
            |..:.|.:..|:.|.:..:.|.:..|.:.:.||||||||::||:|::|...|....|.|||.:..
Mouse   245 LTLVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISE 309

  Fly   373 QTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLD 437
            .:  :..::..::...|..:.:.|.||||::.:||..:|..:::|..::..:.|...:...|||.
Mouse   310 DS--LSQEALNKVITMERVSQRPSYLDLFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGLT 372

  Fly   438 IFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGI----------YS 492
            ::.|..|....|:|:...:..::...|||        |:....||||.:..||          :.
Mouse   373 VYQTQLLFGAVEVPSKITVFFLVRLVGRR--------LTEAGMLLATALTFGISLLVSSDTKSWI 429

  Fly   493 AALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLI 557
            .||.::|:.|...::.....:.:|:.|||:|...:.|..::|.:.:.:||.||.|..:...||.:
Mouse   430 TALVVIGKAFSEAAFTTAYLFTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKL 494

  Fly   558 ILGILGIIGGLLALLLPETLNHVLPQTLSDGEEFGR 593
            ..|.:..:.....||||||....||:|:.|.|..||
Mouse   495 AYGGISFLAACTVLLLPETKKAQLPETIQDVERKGR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	136/503 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	96/353 (27%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	147/535 (27%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	104/380 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850