DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and slc22a8

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	146/545 - (26%)
Similarity:	249/545 - (45%)	Gaps:	43/545 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQ--KLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPEL----DGLD 128
            |.|.::|...|..||:|  :::.:| .|. ..:|.....|.|...||: |.|...:.    :..|
Frog     1 MSFAELLERTGGMGRFQITQVVLLC-FPI-LLMASHNLLQNFSAAIPD-HKCKANDTGYQSNSTD 62

  Fly   129 VEARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKWPQV---------------KCRHG 177
            ......||.|: .||:.:.|    :.|.:|          :|..|               .|..|
Frog    63 ETGYERLSAPLDANGQPDRC----LEYVEI----------QWRMVGSNSTWNNSSELATRPCTIG 113

  Fly   178 WSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMG 242
            |.|:..|.. :|:.||.:.||........||||:..|.:||.::.|.::||:||...||.:....
Frog   114 WEYSKDEFS-STIITEWDLVCGRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQL 177

  Fly   243 LLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACL 307
            .::||..||..|:..:.|.||..|.|..........|::|:|..:.||....:: ...:|....|
Frog   178 AVSGVCAAFSPNYLSYCIFRFLTGMALSGIGLNTTALIVEWVPTRVRTVTGTLA-GFSYTAGQLL 241

  Fly   308 LPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPP 372
            |..:||.:.||:.|.:..|.|..:.....:..||||||||..||.:|||..::|:...||::...
Frog   242 LAGLAYGMRDWRWLQLCVSLPFFIYFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKKEEG 306

  Fly   373 QTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLD 437
            :...:.:...:.::|..:....|||:||.::..:||.:..|.::|.:.|..:.|...::....:.
Frog   307 EKITLESLKSEMIKELASAKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVS 371

  Fly   438 IFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYS--AALAIMGR 500
            |:....:....:.||..:....:...||::....|::|.|:..:....||..:.:  .:||:.|:
Frog   372 IYLIQVIFGAVDFPAKLVSATAMIYVGRKFTQFMSLILGGIAIIANIFVPNELQTVRTSLAVFGK 436

  Fly   501 FFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGII 565
            ..:..|::....:..|:.|||:|...:.....|..:..|:||.|..|..:...:||:|.|...||
Frog   437 GCLAASFSCIFLYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPII 501

  Fly   566 GGLLALLLPETLNHVLPQTLSDGEE 590
            .||....||||:|..||.|:.:.|:
Frog   502 SGLCVFFLPETVNKPLPDTIEEVEK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	126/495 (25%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	90/340 (26%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	110/406 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100