DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and slc22a20p.1

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_004913725.1	Gene:	slc22a20p.1 / 100489586	XenbaseID:	XB-GENE-6463910	Length:	572	Species:	Xenopus tropicalis

Alignment Length:	580	Identity:	174/580 - (30%)
Similarity:	276/580 - (47%)	Gaps:	55/580 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQ----KLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELD----G 126
            |.|:|:|..:|..||:|    .:|.|.|:    |:....|.|.|...:| .|.|.||.||    |
Frog     1 MGFNDLLLSVGGLGRFQIIHTTMLLIPML----FMGCHNFLQNFSAAVP-AHRCWVPSLDNNTMG 60

  Fly   127 LDVEARLALSIPMTNGEYN-NCYMY------------DVNYTDILAQGKVMADPKWPQVKCRHGW 178
            .| :..|...|||...|.. :|..|            ..|:|:                .|..||
Frog    61 YD-QDHLPAFIPMDESEKPLSCLRYRKALHSMWTNGTSTNHTE----------------PCEDGW 108

  Fly   179 SYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGL 243
            .|:.::.. :|:.||.:.||....:...||||:..|.:||.:|.|.::||.||...|||:|::..
Frog   109 VYDKSDFS-STIVTEWDLVCKLRKMRQIAQSIYMAGVLVGAVLLGGLSDRLGRRALLIGSNLVMA 172

  Fly   244 LAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLL 308
            :.|...||:.||..:...|...|.||.........|:||:..||.||.:..: .|..||....||
Frog   173 VCGTCAAFLPNFITYCTFRCLCGIAFSGITLNTNSLILEWTPPKGRTIMGTL-FAAGFTCGQILL 236

  Fly   309 PWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQ 373
            ..:||.:.:|:.|....|||........::||||||||:.:|:..:|:..|:::...||::...|
Frog   237 AALAYGIREWRWLQFAVSAPFYFFFLYSWLVPESARWLILKGRSHEALKALQRVAIINGKREEGQ 301

  Fly   374 TYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDI 438
            .............|.......:|:.|||::|.:|:.|:.|:::|.:..:.|.|...::.:.|:.|
Frog   302 KLSEMILISHMQSELNQVKRPHSLFDLFRTPGMRKVTICLMMVWFSSGVAFYGLGMDLQNFGISI 366

  Fly   439 F---FTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVG--IYSAALAIM 498
            |   |||..   .::||..:..:::...|||....:.::||||..|....:|.|  |....||:.
Frog   367 FLLQFTFGA---IDMPAKVVAALLMTYMGRRVTQATVLILSGVALLTNAFIPQGMKILRMVLAVF 428

  Fly   499 GRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILG 563
            |:..:..|:.....::.|:.|||:|...:..:.:|..|.|::||.|:.|..||..||..|.||..
Frog   429 GKGCMAASFACAYLFSGELFPTVIRQTGMGVVAMMARVGSVVAPLVLLLWEISPILPSAIYGIAA 493

  Fly   564 IIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRN-ADVEEV 622
            ||.|..|..|.||.|..||:::.:.|...:|:.... ..|.::|..::.|.:| |..||:
Frog   494 IIAGGAATFLMETNNQQLPESVEEVEARSQGKHTLK-KVLKEEVPLNQCESQNMAPKEEM 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	145/497 (29%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	104/343 (30%)
slc22a20p.1	XP_004913725.1	MFS	101..485	CDD:391944	118/404 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000