DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and slc22a6

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	155/536 - (28%)
Similarity:	258/536 - (48%)	Gaps:	17/536 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEAR-- 132
            |.|.:||..||..||||.:..:.:....|.:|.....|.|...|| :|.|   :::|...|..
Frog     1 MAFQEILESIGGMGRYQVIHVVLLSLPVFMLASHNLMQNFTAAIP-RHRC---QINGSFEETNFT 61

  Fly   133 ---LALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATE 193
               |...:|| ..||::.|..|......:|.........:.....|..||.|:.:|.. :|:.|:
Frog    62 GPWLRALVPMKPTGEFSKCLRYTTPQYHLLMDNFTQNVDELETETCVDGWVYDHSEFA-STIITQ 125

  Fly   194 QNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEF 258
            .:.||:...:...||||:..|.:||.::||.::|:|||.|..|.:|:...:.|:..||..|:..:
Frog   126 WDLVCNHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQMSVTGICAAFSPNYIWY 190

  Fly   259 AIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAI 323
            .|.||..|.|........|.|::|::....|.|.:. :....:|....:|..:|:.:.||..|.:
Frog   191 CIFRFLTGTALSGIVLNSYSLIVEWIPTGNRAFTST-ATGYCYTMGQLVLVGLAFMIRDWHWLQL 254

  Fly   324 VTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQ--TYQIFTDSCKRMQ 386
            ..|.|........:.:|||.||||..||.:.|...|||:.|.||::...:  |.::...|.:| :
Frog   255 AASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGEKLTVEVLKSSMQR-E 318

  Fly   387 EQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELP 451
            ...:::..||||||.::|.:||.:..:...|.:.|..:.|...::.|.|:.|:....:....::|
Frog   319 ISASKHSTYSVLDLVRTPVVRRISFCISCTWFSTSFAYYGLALDLQSFGVSIYIIQIIFGTVDIP 383

  Fly   452 ADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYS--AALAIMGRFFVNISYNIGLQWA 514
            |......::...|||.|...:::|:|:..|:...||....:  .::|:.|:..:..|:|....:.
Frog   384 AKFFSYFVMTYIGRRVLQALTLILAGIAILVNICVPQDYQTVRTSMAVFGKGCLAASFNCLFLYT 448

  Fly   515 AEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPETLNH 579
            .|:.|||:|...:....:|..:..||||......:|..:|||||.|.|.|:.|:....|||||..
Frog   449 GELYPTVIRQSGMGLGTMMARLGGIIAPLAQMTGDIYHSLPLIIFGCLPILSGIAGCFLPETLGV 513

  Fly   580 VLPQTLSDGEEFGRGQ 595
            .||:|:.|.|...:.|
Frog   514 PLPETIEDVESSDKKQ 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	130/481 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	97/342 (28%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	116/408 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100