DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and si:dkey-166k12.1

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_001341287.1	Gene:	si:dkey-166k12.1 / 100001249	ZFINID:	ZDB-GENE-120215-78	Length:	537	Species:	Danio rerio

Alignment Length:	581	Identity:	171/581 - (29%)
Similarity:	278/581 - (47%)	Gaps:	72/581 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPE----------QHWCHVPEL 124
            |:||.:|..||.||:|||||::.:.....|:.|...:.:|....|.          :.|.....|
Zfish     1 MNFDQLLATIGGFGKYQKLLYVWICLPQIFLGFHMMASVFTGATPPHRCRGSTSGMEDWTFTSNL 65

  Fly   125 DGLDVEARLALSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYAT 189
                  :.:.|||....|..:.|         ..|.|.    .:..:..|..||.|:. |:..:|
Zfish    66 ------SHVNLSISRLAGFADAC---------TAASGV----NRSARTNCETGWVYSH-EVFQST 110

  Fly   190 VATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSN 254
            ..||.:.|||...|.:...||:.||.:||.::||.:|||:||..|::.:..:..:.||..||..|
Zfish   111 TVTEWDLVCDKRGLSSLGSSIYMLGLLVGAVVFGAMADRYGRRFAMLVSLALQTVFGVAAAFAPN 175

  Fly   255 FWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWK 319
            |..:..:||.:|..........::|..|:...: |..:|.:....||.....||..:|:.:.||:
Zfish   176 FPVYVGLRFIIGMTVSGVIINAFVLGTEWTCTQ-RRMLAGIFTDYFFGFGYMLLAGVAFLIRDWR 239

  Fly   320 LLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKR 384
            .|.:..|||..|.||..:|:|.|||||:...:.::|:.:|:|....|||.:|| |.|:     :|
Zfish   240 KLQLAISAPGFLFIFYIWVLPHSARWLLVNNRKEEAIDLLRKAASVNGRTLPP-TVQV-----ER 298

  Fly   385 MQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTE 449
            .:..:.:: ||:|:||.::|::|:..|:|..||....||:.|....|..||.|::.|..:....|
Zfish   299 YESPQGRS-KYTVVDLLRTPQMRKRALILFYIWFVNVLVYYGLSLGVSDLGADLYLTQFMFGLVE 362

  Fly   450 LPADTLLTVILDRFGRRWLACSS-------MVLSGVFSLLATVVPVGIYSA----ALAIMGRFFV 503
            :||.||:.|:        |.||.       :|:.|...||...:|..  ||    |||::|:|.:
Zfish   363 IPARTLVLVL--------LPCSRKIPLSVFLVVGGGACLLTLTLPAD--SAHVRTALAMVGKFGI 417

  Fly   504 NISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGL 568
            ..|:.|...::||:.|||:|...:....:...:..::||.:..|...:..:|::|.|...::...
Zfish   418 TASFAIIYVYSAELFPTVLRQTGIGVSSMFARMGGVLAPLINLLGRHTPVVPMLIFGSTPLLAAA 482

  Fly   569 LALLLPETLNHVLPQTLSDGEEFG---RGQSIWDFPCLAKQVDDDEDEKRNADVEEVRSQA 626
            |||.||||....||.::.|.|:..   .||    .|..|.|      ...|.:.:|::|.|
Zfish   483 LALALPETARQPLPDSIHDTEKSTLKYDGQ----IPVQASQ------SPNNTEGQELQSLA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	143/492 (29%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	109/349 (31%)
si:dkey-166k12.1	XP_001341287.1	2A0119	11..497	CDD:273328	154/523 (29%)
si:dkey-166k12.1	XP_001341287.1	MFS	123..458	CDD:119392	110/352 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950