DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and slc22a5

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	569	Identity:	159/569 - (27%)
Similarity:	276/569 - (48%)	Gaps:	63/569 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDV---EAR 132
            ::|:....:|:.|.:...|| |::...:....::...|........|.|.|      ||   |..
Zfish     3 NYDEDTAFLGQTGPFFIRLF-CLLNLIYISTGLHGLYIVFVAASPAHRCRV------DVNLTEDW 60

  Fly   133 LALSIP---MTNG--EYNNCYMY----------------DVNYTDILAQGKVMADPKWPQVKCRH 176
            |..|.|   ::||  :.:.|:.|                .:|.|||            |:.:|..
Zfish    61 LEASAPTETLSNGDLQVSQCWRYSLQTLTNLSGQGYSPGQINITDI------------PRERCED 113

  Fly   177 GWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMM 241
            ||.|: .::.::|:.:|.:.|||.......|.|..::|.::|.::.|.::|||||...|.|:...
Zfish   114 GWVYS-ADVYHSTIVSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLFGSLAA 177

  Fly   242 GLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAAC 306
            ..|.....:|..::..|.::.||:|....:.:...::|..|.:....|.....:...:.:.....
Zfish   178 EALLMFAQSFSPSWLIFCVLYFFIGAFQISLYITAFVLGNEVLSGSLRVLFTTLGAFLHYCVGYM 242

  Fly   307 LLPWIAYFLADWKLLAIVTSAPLLLAIFTP--FVVPESARWLVSQGKVDKAVGILKKLEKGNGRQ 369
            ||||:|:.:..|:.|..|.|.  |..::.|  :::|||.|||:|||.|.::..||:...:.|  :
Zfish   243 LLPWVAFAIRHWRTLLRVLSG--LTVVYIPLWWLIPESPRWLLSQGHVQESEAILRDAARKN--R 303

  Fly   370 VP-PQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGS 433
            || |:.  ||..|  :::|...|..|||.||:.::..:||||.:.:::||||::.:.|...|..:
Zfish   304 VPAPEV--IFKQS--QIKEAAFQKSKYSALDVLRTSNIRRTTFMCLLLWMAINIGYFGLSLNTTN 364

  Fly   434 LGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYSAALAI- 497
            |..|.|....|:..||:||..:.|.:|....||.:..:.:|:.|.|.||..::|..:.:.|||:
Zfish   365 LSGDPFLNCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLVIGGGFLLLVQLIPDRLQTLALALE 429

  Fly   498 -MGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGI 561
             .|:|...:|:.:...:.||:.|||:|...:........:.||.||::::|...::.||.:::|.
Zfish   430 MAGKFGFTMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYIIFLGTFNRHLPYVLMGS 494

  Fly   562 LGIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDD 610
            |.|...|..|.||||...|||:.|   |:..:.:|   ||...||..:|
Zfish   495 LTITASLANLFLPETFGKVLPENL---EQMQKSRS---FPGRDKQSVED 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	136/500 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	102/343 (30%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	149/531 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950