DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and PRSS12

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_003610.2	Gene:	PRSS12 / 8492	HGNCID:	9477	Length:	875	Species:	Homo sapiens

Alignment Length:	359	Identity:	96/359 - (26%)
Similarity:	144/359 - (40%)	Gaps:	67/359 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YPGPAGLST-----SSSSPF--------SSSGSLEHDAEMSASNVDNRHIKGLGM-----GREMS 88
            |.|||...|     ....|.        .:..||....:......:.||.:..|:     |::.|
Human   543 YKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKAS 607

  Fly    89 ALSEEDDREPLVLNLETTPLMEKMLPEGAMAMDRIFGGDVGNPHCFPYQVGMLLQ--RPKGLYWC 151
            ..|.::.... |..|......:|          ||.||.......:|:||.:.|:  ...|...|
Human   608 GNSNKESLSS-VCGLRLLHRRQK----------RIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLC 661

  Fly   152 GGSLISDKHVITAAHCVDMAKRALVFLGANEIKNAKEKGQVRLMVPSE--------NFQIYPTWN 208
            |.:|:|...|:|||||.   ||    .|.:....|...|....:||.|        ...|:..:.
Human   662 GATLLSSCWVLTAAHCF---KR----YGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYR 719

  Fly   209 PKRLKDDIAIVRL----PHAVSFNERIHPIQLPKRHYEYRSFKNKLA---IASGWGRYATGVHAI 266
            |.|...|||:|||    .....|:..:.|..||.    :|....|.|   ..:|||  .|| .|.
Human   720 PDRSDYDIALVRLQGPEEQCARFSSHVLPACLPL----WRERPQKTASNCYITGWG--DTG-RAY 777

  Fly   267 SNVLRYVQLQIIDGRTCKSNFPLSYRGTNICTSGRNAR---STCNGDSGGPLVLQRRHSKKRVLV 328
            |..|:...:.::..|.|:..:...:.|..:|....:..   .:|.|||||||:.: |..:..|:.
Human   778 SRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCE-RPGESWVVY 841

  Fly   329 GITSFGSIYGCD-RGYPAAFTKVASYLDWISDET 361
            |:||:|  |||. :..|..:|||::::.||...|
Human   842 GVTSWG--YGCGVKDSPGVYTKVSAFVPWIKSVT 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	76/255 (30%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	77/256 (30%)
PRSS12	NP_003610.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..88
		KR	99..164	CDD:214527
		SR	170..270	CDD:214555
		SRCR	175..270	CDD:278931
		SR	280..380	CDD:214555
		SRCR	285..380	CDD:278931
		SR	387..486	CDD:214555
		SRCR	392..485	CDD:278931
		SR	500..599	CDD:214555	11/55 (20%)
		SRCR	510..599	CDD:278931	11/55 (20%)
		Zymogen activation region	619..630		2/20 (10%)
		Tryp_SPc	630..869	CDD:214473	76/255 (30%)
		Tryp_SPc	631..872	CDD:238113	77/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910