DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and PROC

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	244	Identity:	73/244 - (29%)
Similarity:	120/244 - (49%)	Gaps:	17/244 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RIFGGDVGNPHCFPYQVGMLLQRPKGLYWCGGSLISDKHVITAAHCVDMAKRALVFLGANEIKNA 186
            |:..|.:......|:|| :||...|.|. ||..||....|:|||||:|.:|:.||.||..:::.
Human   326 RLIDGKMTRRGDSPWQV-VLLDSKKKLA-CGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRR- 387

  Fly   187 KEKGQVRLMVPSENFQIYPTWNPKRLKDDIAIVRLPHAVSFNERIHPIQLPKRHYEYRSFK--NK 249
            .||.::.|.: .|.| ::|.::.....:|||::.|....:.::.|.||.||......|...  .:
Human   388 WEKWELDLDI-KEVF-VHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQ 450

  Fly   250 LAIASGWGRYATGVHAISN----VLRYVQLQIIDGRTCKSNFPLSYRGTNICTSG--RNARSTCN 308
            ..:.:|||.:::.......    ||.::::.::....| |....:....|:..:|  .:.:..|.
Human   451 ETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNEC-SEVMSNMVSENMLCAGILGDRQDACE 514

  Fly   309 GDSGGPLVLQRRHSKKRVLVGITSFGSIYGCDRGYPAAFTKVASYLDWI 357
            ||||||:|.....:  ..|||:.|:|...|....| ..:|||:.|||||
Human   515 GDSGGPMVASFHGT--WFLVGLVSWGEGCGLLHNY-GVYTKVSRYLDWI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	71/242 (29%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	72/243 (30%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	72/242 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910