DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and PLAU

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens

Alignment Length:	373	Identity:	94/373 - (25%)
Similarity:	155/373 - (41%)	Gaps:	80/373 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YPGPAGLSTSSSS--PFSSSGSLEHDAEMSASNVDNRHIKGLGMGREMSALSEEDDREP---LVL 101
            |.|.|...|....  |::|:..|:.......|:.     ..||:|:.....:.::.|.|   :.:
Human    78 YRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDA-----LQLGLGKHNYCRNPDNRRRPWCYVQV 137

  Fly   102 NLETTPLMEKMLPEGAMAMD---------------------------RIFGGDVGNPHCFPYQVG 139
            .|       |:|.:..|..|                           :|.||:.......|: ..
Human   138 GL-------KLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPW-FA 194

  Fly   140 MLLQRPKG---LYWCGGSLISDKHVITAAHC-VDMAKRA--LVFLGANEIKNAKEKGQVRLMVPS 198
            .:.:|.:|   .|.|||||||...||:|.|| :|..|:.  :|:||.:.: |:..:|:::..|
Human   195 AIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRL-NSNTQGEMKFEV-- 256

  Fly   199 ENFQIYPTWNPKRL--KDDIAIVRL----PHAVSFNERIHPIQLPKRHYEYRSFKNKLAIASGWG 257
            ||..::..::...|  .:|||::::    ......:..|..|.||.. |....|.....| :|:|
Human   257 ENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSM-YNDPQFGTSCEI-TGFG 319

  Fly   258 RYATGVHAISNVLRYVQLQIIDGRTCKSNFPLSYRGTNICTSGRNA------RSTCNGDSGGPLV 316
            :..:..:.....|:...:::|..|.|:..   .|.|:.:.|....|      ..:|.||||||||
Human   320 KENSTDYLYPEQLKMTVVKLISHRECQQP---HYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLV 381

  Fly   317 --LQRRHSKKRVLVGITSFGSIYGCD-RGYPAAFTKVASYLDWISDET 361
              ||.|    ..|.||.|:|.  ||. :..|..:|:|:.:|.||...|
Human   382 CSLQGR----MTLTGIVSWGR--GCALKDKPGVYTRVSHFLPWIRSHT 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	73/255 (29%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	75/256 (29%)
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056	18/85 (21%)
		Connecting peptide	152..177		0/24 (0%)
		Tryp_SPc	179..422	CDD:238113	75/257 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910