DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and HGFAC

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001284368.1	Gene:	HGFAC / 3083	HGNCID:	4894	Length:	662	Species:	Homo sapiens

Alignment Length:	377	Identity:	99/377 - (26%)
Similarity:	154/377 - (40%)	Gaps:	79/377 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YPGPAGLSTSSSSPFSSSGSLEHDAEMSASNVDNRHIKGLGMGR----------------EMSAL 90
            |.|.|..|.|..|..:.:..|.:. |:...:|....:.|||...                :.|||
Human   294 YRGVASTSASGLSCLAWNSDLLYQ-ELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSAL 357

  Fly    91 S-----------EEDDREPLVLNLETTPLMEKMLPEGA---------------MAMDRIFGGDVG 129
            |           |.:.||.|. .::.:|.:...|||.|               ....||.||...
Human   358 SWEYCRLEACDLETEGRESLT-RVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSS 421

  Fly   130 NPHCFPYQVGMLLQRPKGLYWCGGSLISDKHVITAAHCVDMA---KRALVFLGA---NEIKNAKE 188
            .|...|:...:.:    |..:|.|||:....|::||||...:   ....|.||.   |...:..:
Human   422 LPGSHPWLAAIYI----GDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQ 482

  Fly   189 KGQVRLMVPSENFQIYPTWNPKRLKDDIAIVRL----PHAVSFNERIHPIQLPKRHYEYRSFKNK 249
            ...:...:|   :.:|..:||.  ..|:.::||    ....:.::.:.||.||:....:.: .:|
Human   483 TFGIEKYIP---YTLYSVFNPS--DHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPA-GHK 541

  Fly   250 LAIASGWGRYATGVHAISNVLRYVQLQIIDGRTCKSNFPLSYRGTNI-----CTSGRNARS-TCN 308
            ..|| |||.....|...|:.||...:.::....|.|  |..| |.:|     |....:.:| .|.
Human   542 CQIA-GWGHLDENVSGYSSSLREALVPLVADHKCSS--PEVY-GADISPNMLCAGYFDCKSDACQ 602

  Fly   309 GDSGGPLVLQRRHSKKRVLVGITSFGSIYGCDRGY-PAAFTKVASYLDWISD 359
            |||||||..::  :....|.||.|:|.  ||.|.: |..:|:||:|:|||:|
Human   603 GDSGGPLACEK--NGVAYLYGIISWGD--GCGRLHKPGVYTRVANYVDWIND 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	71/251 (28%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	72/252 (29%)
HGFAC	NP_001284368.1	PRR18	34..>169	CDD:292299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..102
		FN2	102..148	CDD:128373
		EGF_CA	162..197	CDD:238011
		FN1	200..240	CDD:238018
		EGF_CA	245..278	CDD:238011
		Kringle	286..367	CDD:278480	16/73 (22%)
		Tryp_SPc	414..648	CDD:214473	71/251 (28%)
		Tryp_SPc	415..650	CDD:238113	72/252 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910