DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and F12

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001014028.1	Gene:	F12 / 306761	RGDID:	1359175	Length:	603	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	86/304 - (28%)
Similarity:	133/304 - (43%)	Gaps:	57/304 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 MSALSEEDDREPLVLNLETTPLMEKMLPEGAMAMDRIFGGDVGNPHCFPYQVGMLLQRPKGLYW- 150
            :|...:...|...|::..:|.:..:...:...::.|:.||.|..|...||..        .|||
  Rat   326 LSDALDNSTRNQNVVSRTSTVVCGQRFRKRLSSLRRVVGGLVALPGSHPYIA--------ALYWG 382

  Fly   151 ---CGGSLISDKHVITAAHCVD---MAKRALVFLGANEIKNAKEKGQVRLMVPSENFQIYPTWNP 209
               |.||||....|:|||||:.   ..:...|.||.:....:.|:.|. |.|.|  ::::..::.
  Rat   383 DSFCAGSLIDPCWVLTAAHCLQKRPAPEELTVVLGQDRHNQSCERCQT-LAVHS--YRLHEGFSS 444

  Fly   210 KRLKDDIAIVRL-----------PHAVSFNERIHPIQLPKRHYEYRSFKNKLAIASGWGRYATGV 263
            |..:.|:|::||           ||       :.|:.||..  .....:..|...:|||....|.
  Rat   445 KTYQHDLALLRLRGRKNSCAILSPH-------VQPVCLPSS--AAPPSETVLCEVAGWGHQFEGA 500

  Fly   264 HAISNVLRYVQLQIIDGRTCKSNFPLSYRGTNI-----CT----SGRNARSTCNGDSGGPLVLQR 319
            ...:..|:..|:..|....|.|:   :..|..|     |.    .|.:|   |.||||||||...
  Rat   501 EEYATFLQEAQVPFISLDRCSSS---NVHGDAILPGMLCAGFLEGGADA---CQGDSGGPLVCDE 559

  Fly   320 RHSKKRV-LVGITSFGSIYGC-DRGYPAAFTKVASYLDWISDET 361
            ..::::: |.|:.|:||  || ||..|..:|.||:|||||.:.|
  Rat   560 GVTERQLTLRGVISWGS--GCGDRNKPGVYTDVANYLDWIQEHT 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	79/263 (30%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	80/264 (30%)
F12	NP_001014028.1	FN2	40..87	CDD:238019
		EGF_CA	95..130	CDD:238011
		FN1	132..170	CDD:238018
		EGF	177..207	CDD:278437
		Kringle	216..294	CDD:278480
		Tryp_SPc	361..597	CDD:214473	79/263 (30%)
		Tryp_SPc	362..600	CDD:238113	80/265 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910