DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6592 and F2

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	95/344 - (27%)
Similarity:	144/344 - (41%)	Gaps:	77/344 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GSLEHDAEMSASNVDNRHIKGLGMGREMSA------------LSEED-DREPLVLNLETTPLMEK 111
            |...||.:.|.:            ||...|            |.|.| ...||......|...||
  Rat   297 GEENHDGDESIA------------GRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEK 349

  Fly   112 MLPEGAMAMDRIFGGDVGNPHCFPYQVGMLLQRPKGLYWCGGSLISDKHVITAAHCV-------- 168
            .|.:..:. .||..|........|:||.:..:.|:.|. ||.|||||:.|:|||||:
  Rat   350 ELLDSYID-GRIVEGWDAEKGIAPWQVMLFRKSPQELL-CGASLISDRWVLTAAHCILYPPWDKN 412

  Fly   169 ----DMAKRALVFLGANEIKNAKEKGQVRLMVPSENFQIYPTWN-PKRLKDDIAIVRLPHAVSFN 228
                |:    ||.:|.:  ...:.:..|..:...|...|:|.:| .:.|..|||:::|...|.|:
  Rat   413 FTENDL----LVRIGKH--SRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFS 471

  Fly   229 ERIHPIQLPKRH---------YEYRSFKNKLAIASGWGR----YATGVHAIS-NVLRYVQLQIID 279
            :.|||:.||.:.         |:.|        .:|||.    :.|.::.|. :||:.|.|.|::
  Rat   472 DYIHPVCLPDKQTVTSLLQAGYKGR--------VTGWGNLRETWTTNINEIQPSVLQVVNLPIVE 528

  Fly   280 GRTCKSNFPLSYRGTNICTSGRNARST-----CNGDSGGPLVLQRRHSKKRVLVGITSFGSIYGC 339
            ...||::..:.......| :|.....|     |.||||||.|::..::.:...:||.|:|.  ||
  Rat   529 RPVCKASTRIRITDNMFC-AGFKVNDTKRGDACEGDSGGPFVMKSPYNHRWYQMGIVSWGE--GC 590

  Fly   340 DR-GYPAAFTKVASYLDWI 357
            || |....:|.|.....|:
  Rat   591 DRNGKYGFYTHVFRLKRWM 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	78/267 (29%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	78/268 (29%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480
		Thrombin_light	312..359	CDD:286482	10/47 (21%)
		Tryp_SPc	359..608	CDD:214473	78/266 (29%)
		Tryp_SPc	360..612	CDD:238113	78/268 (29%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910