DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and TMPRSS11E

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_054777.2	Gene:	TMPRSS11E / 28983	HGNCID:	24465	Length:	423	Species:	Homo sapiens

Alignment Length:	260	Identity:	75/260 - (28%)
Similarity:	117/260 - (45%)	Gaps:	45/260 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RIFGGDVGNPHCFPYQVGMLLQRPKGLYWCGGSLISDKHVITAAHCVDMAK---RALVFLGANEI 183
            ||.||.......:|:|..:   :..|.:.||.:||:...:::||||....|   |.....|.. |
Human   191 RIVGGTEVEEGEWPWQASL---QWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVT-I 251

  Fly   184 KNAKEKGQVRLMVPSENFQIYPTWNPKRLKDDIAIVRLPHAVSFNERIHPIQLPKRHYEYRSFKN 248
            |.:|.|..:|.::..|.:: :|:.:     .||::..|...|.:...:|.:.||...||::
Human   252 KPSKMKRGLRRIIVHEKYK-HPSHD-----YDISLAELSSPVPYTNAVHRVCLPDASYEFQ---- 306

  Fly   249 KLAIASGWGRYATGVHAI------SNVLRYVQLQIIDGRTCKSNFPLSYRGT----NICTSGRNA 303
                 .|...:.||..|:      .|.||..|:.:||..||  |.|.:|...    .:|......
Human   307 -----PGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTC--NEPQAYNDAITPRMLCAGSLEG 364

  Fly   304 RS-TCNGDSGGPLVLQRRHSKKR---VLVGITSFGSIYGCDR-GYPAAFTKVASYLDWISDETGV 363
            :: .|.||||||||    .|..|   .|.||.|:|.  .|.: ..|..:|:|.:..|||:.:||:
Human   365 KTDACQGDSGGPLV----SSDARDIWYLAGIVSWGD--ECAKPNKPGVYTRVTALRDWITSKTGI 423

Fly 364 363
Human 424 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	71/252 (28%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	72/253 (28%)
TMPRSS11E	NP_054777.2	SEA	51..156	CDD:307516
TMPRSS11E	NP_054777.2	Tryp_SPc	192..420	CDD:238113	72/254 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910