DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and F12

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	272	Identity:	81/272 - (29%)
Similarity:	123/272 - (45%)	Gaps:	44/272 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LPEGAMAMDRIFGGDVGNPHCFPYQVGMLLQRPKGLYW----CGGSLISDKHVITAAHCVD---M 170
            |.:...:|.|:.||.|......||..        .|||    |.||||:...|:|||||:.   .
Human   363 LRKSLSSMTRVVGGLVALRGAHPYIA--------ALYWGHSFCAGSLIAPCWVLTAAHCLQDRPA 419

  Fly   171 AKRALVFLGANEIKNAKEKGQVRLMVPSENFQIYPTWNPKRLKDDIAIVRLPH-----AVSFNER 230
            .:...|.||.....::.|..|. |.|.|  ::::..::|...:.|:|::||..     ....:..
Human   420 PEDLTVVLGQERRNHSCEPCQT-LAVRS--YRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPY 481

  Fly   231 IHPIQLPKRHYEYRSFKNKLAIASGWGRYATGVHAISNVLRYVQLQIIDGRTCKSNFPLSYRGTN 295
            :.|:.||..  ..|..:..|...:|||....|....::.|:..|:..:....|.:.   ...|::
Human   482 VQPVCLPSG--AARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAP---DVHGSS 541

  Fly   296 I-----CT----SGRNARSTCNGDSGGPLVLQRRHSKKRV-LVGITSFGSIYGC-DRGYPAAFTK 349
            |     |.    .|.:|   |.||||||||.:.:.:::|: |.||.|:||  || ||..|..:|.
Human   542 ILPGMLCAGFLEGGTDA---CQGDSGGPLVCEDQAAERRLTLQGIISWGS--GCGDRNKPGVYTD 601

  Fly   350 VASYLDWISDET 361
            ||.||.||.:.|
Human   602 VAYYLAWIREHT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	76/257 (30%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	77/258 (30%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359
		Tryp_SPc	372..609	CDD:214473	76/257 (30%)
		Tryp_SPc	373..612	CDD:238113	77/259 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910