DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6592 and F2

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	308	Identity:	86/308 - (27%)
Similarity:	136/308 - (44%)	Gaps:	60/308 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 EMSALSEEDDREPLVLNLETTPLMEKMLPEGAMAMDRIFGGDVGNPHCFPYQVGMLLQRPKGLYW 150
            |..:|.::.:||          |:|..: :|     ||..|........|:||.:..:.|:.|.
Human   343 EKKSLEDKTERE----------LLESYI-DG-----RIVEGSDAEIGMSPWQVMLFRKSPQELL- 390

  Fly   151 CGGSLISDKHVITAAHCV------------DMAKRALVFLGANEIKNAKEKGQVRLMVPSENFQI 203
            ||.|||||:.|:|||||:            |:    ||.:|.:  ...:.:..:..:...|...|
Human   391 CGASLISDRWVLTAAHCLLYPPWDKNFTENDL----LVRIGKH--SRTRYERNIEKISMLEKIYI 449

  Fly   204 YPTWN-PKRLKDDIAIVRLPHAVSFNERIHPIQLPKRHYE----YRSFKNKLAIASGWGRY---- 259
            :|.:| .:.|..|||:::|...|:|::.|||:.||.|...    ...:|.::   :|||..
Human   450 HPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRV---TGWGNLKETW 511

  Fly   260 -ATGVHAISNVLRYVQLQIIDGRTCKSNFPLSYRGTNICT-----SGRNARSTCNGDSGGPLVLQ 318
             |.......:||:.|.|.|::...||.:..:.......|.     .|:.. ..|.||||||.|::
Human   512 TANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMK 575

  Fly   319 RRHSKKRVLVGITSFGSIYGCDR-GYPAAFTKVASYLDWIS---DETG 362
            ...:.:...:||.|:|.  |||| |....:|.|.....||.   |:.|
Human   576 SPFNNRWYQMGIVSWGE--GCDRDGKYGFYTHVFRLKKWIQKVIDQFG 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	75/262 (29%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	76/266 (29%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056
		KR	211..293	CDD:214527
		Thrombin_light	317..363	CDD:286482	7/35 (20%)
		Tryp_SPc	363..613	CDD:214473	75/262 (29%)
		Tryp_SPc	364..616	CDD:238113	76/264 (29%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910