DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6592 and Prss12

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	281	Identity:	82/281 - (29%)
Similarity:	122/281 - (43%)	Gaps:	44/281 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EKMLPEGA------MAMDRIFGGDVGNPHCFPYQVGMLLQ--RPKGLYWCGGSLISDKHVITAAH 166
            ::||..|.      ....||.||:......:|:|..:.|:  ...|...||.:|:|...|:||||
Mouse   498 KEMLSSGCGLRLLHRRQKRIIGGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAH 562

  Fly   167 CVDMAKRALVFLGANEIKNAKEKGQVRLMVPSENFQ--------IYPTWNPKRLKDDIAIVRL-- 221
            |.   ||    .|.|....|...|....:||.|..|        |:..:.|.|...|||:|||
Mouse   563 CF---KR----YGNNSRSYAVRVGDYHTLVPEEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQG 620

  Fly   222 --PHAVSFNERIHPIQLPKRHYEYRSFKNKLAI---ASGWGRYATGVHAISNVLRYVQLQIIDGR 281
              ......:..:.|..||.    :|....|.|.   .:|||  .|| .|.|..|:...:.::..|
Mouse   621 PGEQCARLSTHVLPACLPL----WRERPQKTASNCHITGWG--DTG-RAYSRTLQQAAVPLLPKR 678

  Fly   282 TCKSNFPLSYRGTNICTSG---RNARSTCNGDSGGPLVLQRRHSKKRVLVGITSFGSIYGCD-RG 342
            .||..:...:.|..:|...   .|...:|.|||||||:.: :..:..|:.|:||:|  |||. :.
Mouse   679 FCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCE-KPDESWVVYGVTSWG--YGCGVKD 740

  Fly   343 YPAAFTKVASYLDWISDETGV 363
            .|..:|:|.:::.||...|.:
Mouse   741 TPGVYTRVPAFVPWIKSVTSL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	76/255 (30%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	77/256 (30%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	396..485	CDD:278931
		Zymogen activation region	505..516		0/10 (0%)
		Tryp_SPc	516..755	CDD:214473	76/255 (30%)
		Tryp_SPc	517..758	CDD:238113	77/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000