DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6592 and F2

DIOPT Version :9

Sequence 1:	NP_648016.1	Gene:	CG6592 / 38687	FlyBaseID:	FBgn0035669	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_034298.1	Gene:	F2 / 14061	MGIID:	88380	Length:	618	Species:	Mus musculus

Alignment Length:	329	Identity:	89/329 - (27%)
Similarity:	143/329 - (43%)	Gaps:	79/329 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KGLGMGR---------EMSALSEEDDREPLVLNLETTPLMEKMLPEGAMAMDRIFGGDVGNPHCF 134
            |..|:|.         |..:|.:..::|          |::..: :|     ||..|........
Mouse   324 KTFGLGEADCGLRPLFEKKSLKDTTEKE----------LLDSYI-DG-----RIVEGWDAEKGIA 372

  Fly   135 PYQVGMLLQRPKGLYWCGGSLISDKHVITAAHCV------------DMAKRALVFLGANEIKNAK 187
            |:||.:..:.|:.|. ||.|||||:.|:|||||:            |:    ||.:|.:  ...:
Mouse   373 PWQVMLFRKSPQELL-CGASLISDRWVLTAAHCILYPPWDKNFTENDL----LVRIGKH--SRTR 430

  Fly   188 EKGQVRLMVPSENFQIYPTWN-PKRLKDDIAIVRLPHAVSFNERIHPIQLPKRH---------YE 242
            .:..|..:...|...::|.:| .:.|..|||:::|...|.|::.|||:.||.:.         |:
Mouse   431 YERNVEKISMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYK 495

  Fly   243 YRSFKNKLAIASGWGR----YATGVHAIS-NVLRYVQLQIIDGRTCKSNFPLSYRGTNICTSGRN 302
            .|        .:|||.    :.|.::.|. :||:.|.|.|::...||::..:.......| :|..
Mouse   496 GR--------VTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFC-AGFK 551

  Fly   303 ARST-----CNGDSGGPLVLQRRHSKKRVLVGITSFGSIYGCDR-GYPAAFTKVASYLDWIS--- 358
            ...|     |.||||||.|::...:.:...:||.|:|.  |||| |....:|.|.....||.
Mouse   552 VNDTKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGE--GCDRKGKYGFYTHVFRLKRWIQKVI 614

  Fly   359 DETG 362
            |:.|
Mouse   615 DQFG 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6592	NP_648016.1	Tryp_SPc	122..357	CDD:214473	77/267 (29%)
CG6592	NP_648016.1	Tryp_SPc	123..359	CDD:238113	78/271 (29%)
F2	NP_034298.1	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		KR	213..295	CDD:214527
		Thrombin_light	313..360	CDD:286482	8/51 (16%)
		Tryp_SPc	360..610	CDD:214473	77/267 (29%)
		Tryp_SPc	361..613	CDD:238113	78/269 (29%)
		High affinity receptor-binding region which is also known as the TP508 peptide. /evidence=ECO:0000250	548..570		9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910