DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon65Ai and PROC

DIOPT Version :9

Sequence 1:	NP_001286951.1	Gene:	Jon65Ai / 38685	FlyBaseID:	FBgn0035667	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	254	Identity:	65/254 - (25%)
Similarity:	110/254 - (43%)	Gaps:	31/254 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KDVPVGKASIEGRITMGYPAYEGKVPYIVGLGFSKNGGGTWCGGSIIGNTWVMTAKHCTDGMESV 89
            :|....:..::.|:..|.....|..|:.|.|..||.  ...||..:|..:||:||.||.|..:.:
Human   314 RDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKK--KLACGAVLIHPSWVLTAAHCMDESKKL 376

  Fly    90 TIYYGAL-------WRLQAQYTHWVGRSDFIEHGS-GDISLIRTPHVDFWSLVNKVELP------ 140
            .:..|..       |.|...........::.:..: .||:|:   |:...:.:::..:|
Human   377 LVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALL---HLAQPATLSQTIVPICLPDS 438

  Fly   141 RYDDRYNNYQGWWALVSGWGKTSDEGGVSE-----YLNCVDVQIGENSVCENYYGSF-SGDLICI 199
            ...:|..|..|...||:|||..|.....::     .||.:.:.:..::.|.....:. |.:::|.
Human   439 GLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCA 503

  Fly   200 P-TPENKGTCSGDSGGPLV--IHDGNRQVGIVSFGSSAGCLSNGPKGM-VRVTSYLDWI 254
            . ..:.:..|.||||||:|  .|.....||:||:|...|.|.|  .|: .:|:.|||||
Human   504 GILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHN--YGVYTKVSRYLDWI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon65Ai	NP_001286951.1	Tryp_SPc	37..254	CDD:214473	62/240 (26%)
Jon65Ai	NP_001286951.1	Tryp_SPc	41..257	CDD:238113	63/238 (26%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	63/240 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910