Protein Alignment Jon65Aiii and KLK1

DIOPT Version :10

• Sequence 1: NP_648013.1
• Gene: Jon65Aiii / 38683
• FlyBaseID: FBgn0035665
• Length: 274
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 79/278 - (28%)
• Similarity: 111/278 - (39%)
• Gaps: 41/278 - (14%)

  Fly     5 VVFALALATASAGLLPQQVPIHPRDLPAVTNIEGRITNGKTATSGQFPYQVGLSFASTSGSWWCG 69
            :|..|||:....|..|.              |:.||..|........|:|..|...||   :.||
Human     4 LVLCLALSLGGTGAAPP--------------IQSRIVGGWECEQHSQPWQAALYHFST---FQCG 51

  Fly    70 GSIIDNTWVLTAAHCTSGASAVTIYYGA-TVRTSAQLVQTVSADNFVQHASYNSIVLRN------ 127
            |.::...||||||||.|  ....::.|. .:.......|.|.......|..:|..:|.|
Human    52 GILVHRQWVLTAAHCIS--DNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQAD 114

  Fly   128 -----DISLIK--TPTVAFTALINKVELPAIAGTYSTYTGQQAIASGWGKTSDSATSVANTLQYE 185
                 |:.|::  .|....|..:..||||    |.....|...:|||||.......|..:.||..
Human   115 EDYSHDLMLLRLTEPADTITDAVKVVELP----TEEPEVGSTCLASGWGSIEPENFSFPDDLQCV 175

  Fly   186 VFEVVSVSQCQNTYGSLVATNNVICVA-TPNKVSTCNGDSGGPLVLVSDSKLIGVTSFVSSAGCE 249
            ..:::...:|:..:...| |:.::||. ......||.||||||  |:.|..|.||||:.......
Human   176 DLKILPNDECKKAHVQKV-TDFMLCVGHLEGGKDTCVGDSGGP--LMCDGVLQGVTSWGYVPCGT 237

  Fly   250 SGAPAGFTRVTSYLDWIK 267
            ...|:...||.||:.||:
Human   238 PNKPSVAVRVLSYVKWIE 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jon65Aiii	NP_648013.1	Tryp_SPc	39..266	CDD:214473	70/241 (29%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	71/243 (29%)