DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6462 and ST14

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_068813.1	Gene:	ST14 / 6768	HGNCID:	11344	Length:	855	Species:	Homo sapiens

Alignment Length:	302	Identity:	87/302 - (28%)
Similarity:	133/302 - (44%)	Gaps:	54/302 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KEETPDDDDAIMERRWQLGYENFRLRCEKFEMEGNQTAAVRTRIAGGELATRGMFPYQVGLVIQL 98
            ||:..|..|   |:....|..:|               ..:.|:.||..|..|.:|:||.|  ..
Human   590 KEDCSDGSD---EKDCDCGLRSF---------------TRQARVVGGTDADEGEWPWQVSL--HA 634

  Fly    99 SGADLVKCGGSLITLQFVLTAAHCLTDAIAAKIY--TGATVFADVED-------SVEELQVTHRD 154
            .|...: ||.|||:..::::||||..|....:..  |..|.|..:.|       .|:|.::  :.
Human   635 LGQGHI-CGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRL--KR 696

  Fly   155 FIIYPDYLGFGGYSDLALIRLPRKVRTSEQVQPIELAGEFMHQNFLVGKVVTLSGWG---YLGDS 216
            .|.:|.:..|....|:||:.|.:....|..|:||.|. :..|. |..||.:.::|||   |.|..
Human   697 IISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLP-DASHV-FPAGKAIWVTGWGHTQYGGTG 759

  Fly   217 TDKRTRLLQYLDAEVIDQERCICYFLPGLVSQRRHLCTDGSNGRGACNGDSGGPVVYHWRNVS-- 279
                ..:||..:..||:|..|. ..||..::.|.......|.|..:|.||||||:    .:|.
Human   760 ----ALILQKGEIRVINQTTCE-NLLPQQITPRMMCVGFLSGGVDSCQGDSGGPL----SSVEAD 815

  Fly   280 ---YLIGVTSFGSAEGC-EVGGPTVYTRITAYLPWIRQQTAM 317
               :..||.|:|  :|| :...|.||||:..:..||::.|.:
Human   816 GRIFQAGVVSWG--DGCAQRNKPGVYTRLPLFRDWIKENTGV 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	77/252 (31%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	78/254 (31%)
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SEA	88..>171	CDD:307516
		CUB	227..332	CDD:238001
		CUB	340..444	CDD:238001
		LDLa	454..486	CDD:238060
		LDLa	488..523	CDD:238060
		LDLa	525..559	CDD:238060
		LDLa	567..602	CDD:238060	5/14 (36%)
		Tryp_SPc	615..852	CDD:238113	78/254 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910