Protein Alignment CG6462 and TMPRSS4

DIOPT Version :10

• Sequence 1: NP_648011.1
• Gene: CG6462 / 38681
• FlyBaseID: FBgn0035663
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: XP_005271670.1
• Gene: TMPRSS4 / 56649
• HGNCID: 11878
• Length: 494
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 97/318 - (30%)
• Similarity: 144/318 - (45%)
• Gaps: 62/318 - (19%)

  Fly    22 SSEPWLDTFEHPKEETPDDD-DA--IMERRWQLGYENFRLRCEKFEMEGNQTA--------AVRT 75
            ||:|   || ...|..||.| |.  |.|...:|...|....|    :.|:..:        :::|
Human   146 SSKP---TF-RAVEIGPDQDLDVVEITENSQELRMRNSSGPC----LSGSLVSLHCLACGKSLKT 202

  Fly    76 -RIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCL---TDAIAAKIYTGAT 136
             |:.|.|.|:...:|:||.  ||.....:  ||||::...:|||||||.   ||....|:..|
Human   203 PRVVGVEEASVDSWPWQVS--IQYDKQHV--CGGSILDPHWVLTAAHCFRKHTDVFNWKVRAG-- 261

  Fly   137 VFADVEDSVEELQVTHRDFI----IYPDYLGFGGYSDLALIRLPRKVRTSEQVQPIELAGEFMHQ 197
              :|...|...|.|.....|    :||.      .:|:||::|...:..|..|:||.|  .|..:
Human   262 --SDKLGSFPSLAVAKIIIIEFNPMYPK------DNDIALMKLQFPLTFSGTVRPICL--PFFDE 316

  Fly   198 NFLVGKVVTLSGWGYLGDSTDKRTRLLQYLDAEVIDQERC---ICYFLPGLVSQRRHLCTDGSNG 259
            .......:.:.|||:...:..|.:.:|.....:|||..||   ..|  .|.|:::.........|
Human   317 ELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAY--QGEVTEKMMCAGIPEGG 379

  Fly   260 RGACNGDSGGPVVY---HWRNVSYLIGVTSFGSAEGCEVGGPT---VYTRITAYLPWI 311
            ...|.||||||::|   .|    :::|:.|:|  .||  |||:   |||:::|||.||
Human   380 VDTCQGDSGGPLMYQSDQW----HVVGIVSWG--YGC--GGPSTPGVYTKVSAYLNWI 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	79/251 (31%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:470597	16/58 (28%)
		Tryp_SPc	204..429	CDD:214473	78/250 (31%)