DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and MASP1

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	281	Identity:	74/281 - (26%)
Similarity:	123/281 - (43%)	Gaps:	51/281 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RIAGGELATRGMFPYQVGLVIQLSGA---DLVKCGGSLITLQFVLTAAHCL------TDAIAAK- 130
            ||.||..|..|:||:|..:|::.:..   |.....|:|::..::|||||.|      |..|...
Human   456 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSK 520

  Fly   131 ----IYTGATVFADVEDSVEELQVTHRDFIIYPDYLGFGGYS-DLALIRLPRKVRTSEQVQPI-- 188
                :|.|   ..||.|....:..:....:::||: ....|: |:||::|...|.....|.|:
Human   521 EHVTVYLG---LHDVRDKSGAVNSSAARVVLHPDF-NIQNYNHDIALVQLQEPVPLGPHVMPVCL 581

  Fly   189 ---ELAGEFMHQNFLVGKVVTLSGWG----------YLGDSTDKRTRLLQYLDAEVIDQERCICY 240
               |..|...|...||      :|||          .:...|...:.:|||:...|:....|...
Human   582 PRLEPEGPAPHMLGLV------AGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTS 640

  Fly   241 F--LPGLVSQRRHLCTDG--SNGRGACNGDSGGP-VVYHWRNVSYLI-GVTSFGSAEGC---EVG 296
            :  ..|..|...::...|  ..|:..|.|||||. |::...:..::: |:.|:|..|.|   :|.
Human   641 YESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVY 705

  Fly   297 GPTVYTRITAYLPWIRQQTAM 317
            |  |||:::.|:.|:.:|..:
Human   706 G--VYTKVSNYVDWVWEQMGL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	72/273 (26%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	72/275 (26%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056
		Tryp_SPc	456..718	CDD:214473	72/273 (26%)
		Tryp_SPc	457..718	CDD:238113	71/272 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910