DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and PLG

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_000292.1	Gene:	PLG / 5340	HGNCID:	9071	Length:	810	Species:	Homo sapiens

Alignment Length:	266	Identity:	81/266 - (30%)
Similarity:	128/266 - (48%)	Gaps:	43/266 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CEKFEMEGNQTAAVRTRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCLT 124
            |.|.::|..:...   |:.||.:|....:|:||.|..:..   :..|||:||:.::||||||||.
Human   567 CGKPQVEPKKCPG---RVVGGCVAHPHSWPWQVSLRTRFG---MHFCGGTLISPEWVLTAAHCLE 625

  Fly   125 DA---IAAKIYTGATVFADVEDSVEELQVTHRDFIIYPDYLGFGGYSDLALIRLPRKVRTSEQVQ 186
            .:   .:.|:..||....::|..|:|::|:.  ..:.|.      ..|:||::|......:::|.
Human   626 KSPRPSSYKVILGAHQEVNLEPHVQEIEVSR--LFLEPT------RKDIALLKLSSPAVITDKVI 682

  Fly   187 PIELAGEFMHQNFLVGKVVT--LSGWGYLGDSTDKRTR------LLQYLDAEVIDQERCICY-FL 242
            |..|..    .|::|.....  ::|||        .|:      ||:.....||:.:.|..| ||
Human   683 PACLPS----PNYVVADRTECFITGWG--------ETQGTFGAGLLKEAQLPVIENKVCNRYEFL 735

  Fly   243 PGLVSQRRHLCTDG-SNGRGACNGDSGGPVVYHWRNVSYLIGVTSFGSAEGC-EVGGPTVYTRIT 305
            .|.| |...||... :.|..:|.||||||:|...::...|.||||:|.  || ....|.||.|::
Human   736 NGRV-QSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGL--GCARPNKPGVYVRVS 797

  Fly   306 AYLPWI 311
            .::.||
Human   798 RFVTWI 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	76/248 (31%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	77/249 (31%)
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527
		KR	273..354	CDD:214527
		KR	375..456	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
		KR	479..560	CDD:214527
		Tryp_SPc	580..803	CDD:214473	76/248 (31%)
		Tryp_SPc	581..804	CDD:238113	77/249 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910