Protein Alignment CG6462 and KLK1

DIOPT Version :10

• Sequence 1: NP_648011.1
• Gene: CG6462 / 38681
• FlyBaseID: FBgn0035663
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 77/286 - (26%)
• Similarity: 120/286 - (41%)
• Gaps: 54/286 - (18%)

  Fly    56 FRLRCEKFEMEGNQTA-AVRTRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTA 119
            |.:.|....:.|...| .:::||.||....:...|:|..|.    .....:|||.|:..|:||||
Human     3 FLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALY----HFSTFQCGGILVHRQWVLTA 63

  Fly   120 AHCLTDAIAAKIYTGATVFADVEDSVEELQVTHRDFIIYPDYLGFG-------------GYS-DL 170
            |||::|..  :::.|.....|.|::.:.:.|:..    :| :.||.             .|| ||
Human    64 AHCISDNY--QLWLGRHNLFDDENTAQFVHVSES----FP-HPGFNMSLLENHTRQADEDYSHDL 121

  Fly   171 ALIRLPRKVRT-SEQVQPIELAGEFMHQNFLVGKVVTLSGWGYLGDSTDKRTRLLQYLDAEVIDQ 234
            .|:||.....| ::.|:.:||..|...    ||.....||||.:..........||.:|.:::..
Human   122 MLLRLTEPADTITDAVKVVELPTEEPE----VGSTCLASGWGSIEPENFSFPDDLQCVDLKILPN 182

  Fly   235 ERCICYFLPGLVSQRRH--------LCTDG-SNGRGACNGDSGGPVVYHWRNVSYLIGVTSFGSA 290
            :.|          ::.|        ||... ..|:..|.||||||::..    ..|.||||:|..
Human   183 DEC----------KKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCD----GVLQGVTSWGYV 233

  Fly   291 EGCEVGGPTVYTRITAYLPWIRQQTA 316
            .......|:|..|:.:|:.||....|
Human   234 PCGTPNKPSVAVRVLSYVKWIEDTIA 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	71/260 (27%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	71/260 (27%)