DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and prss60.3

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	XP_002662541.2	Gene:	prss60.3 / 335152	ZFINID:	ZDB-GENE-030131-7092	Length:	330	Species:	Danio rerio

Alignment Length:	254	Identity:	78/254 - (30%)
Similarity:	121/254 - (47%)	Gaps:	18/254 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 AAVRTRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCLT--DAIAAKIYT 133
            |.:.|||.||..|:.|.:|:||.|.....|...  ||||||:.::||||||||:  ......:|.
Zfish    30 APLNTRIVGGVNASPGSWPWQVSLHSPKYGGHF--CGGSLISSEWVLTAAHCLSGVSETTLVVYL 92

  Fly   134 GATVFADVEDSVEELQVTHRDFIIYPDYLGFGGYSDLALIRLPRKVRTSEQVQPIELAGEFMHQN 198
            |......:  ::.|.........::..|......:|:||:||...|..:..::|:.||.:  :..
Zfish    93 GRRTQQGI--NIYETSRNVAKSFVHSSYNSNTNDNDIALLRLSSAVTFTNYIRPVCLAAQ--NSV 153

  Fly   199 FLVGKVVTLSGWGYLGDSTD-KRTRLLQYLDAEVIDQERCICYFLPGLVSQRRHLC---TDGSNG 259
            :..|....::|||.:....: ....:||.....|:..:||......|.|:... :|   |.|  |
Zfish   154 YSAGTSSWITGWGDIQAGVNLPAPGILQETMIPVVANDRCNALLGSGTVTNNM-ICAGLTQG--G 215

  Fly   260 RGACNGDSGGPVVYHWRNVSYLIGVTSFGSAEGC-EVGGPTVYTRITAYLPWIRQQTAM 317
            :..|.||||||:|.....|....|:||:|  .|| :...|.||||::.|..||..:.::
Zfish   216 KDTCQGDSGGPMVTRLCTVWVQAGITSWG--YGCADPNSPGVYTRVSQYQSWISSKISL 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	74/241 (31%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	75/243 (31%)
prss60.3	XP_002662541.2	Tryp_SPc	36..269	CDD:238113	75/243 (31%)
prss60.3	XP_002662541.2	Somatomedin_B	294..328	CDD:321959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.030