DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and HGFAC

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001284368.1	Gene:	HGFAC / 3083	HGNCID:	4894	Length:	662	Species:	Homo sapiens

Alignment Length:	334	Identity:	88/334 - (26%)
Similarity:	132/334 - (39%)	Gaps:	68/334 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HPKEETPDDDDAIMERRW-------QLGYENFRLRCEKFEMEGNQTAA----------------- 72
            |.....||:|    ||.|       .|.:|..||.....|.||.::..
Human   335 HAYCRNPDND----ERPWCYVVKDSALSWEYCRLEACDLETEGRESLTRVQLSPDLLATLPEPAS 395

  Fly    73 ---------------VRTRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHC 122
                           :|.||.||..:..|..|:...:.|..|     .|.|||:...:|::||||
Human   396 PGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDS-----FCAGSLVHTCWVVSAAHC 455

  Fly   123 LT-----DAIAAKIYTGATVFADVEDSVEELQVTHRDFIIYPDYLGFG-GYSDLALIRLPRK--- 178
            .:     |:::  :..|...|....|..:...:  ..:|.|..|..|. ...||.||||.:|
Human   456 FSHSPPRDSVS--VVLGQHFFNRTTDVTQTFGI--EKYIPYTLYSVFNPSDHDLVLIRLKKKGDR 516

  Fly   179 -VRTSEQVQPIELAGEFMHQNFLVGKVVTLSGWGYLGDSTDKRTRLLQYLDAEVIDQERCICYFL 242
             ...|:.||||.|...  ...|..|....::|||:|.::....:..|:.....::...:|....:
Human   517 CATRSQFVQPICLPEP--GSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEV 579

  Fly   243 PGLVSQRRHLCTDGSNGRG-ACNGDSGGPVVYHWRNVSYLIGVTSFGSAEGC-EVGGPTVYTRIT 305
            .|.......||....:.:. ||.||||||:......|:||.|:.|:|  :|| .:..|.||||:.
Human   580 YGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWG--DGCGRLHKPGVYTRVA 642

  Fly   306 AYLPWIRQQ 314
            .|:.||..:
Human   643 NYVDWINDR 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	71/246 (29%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	72/248 (29%)
HGFAC	NP_001284368.1	PRR18	34..>169	CDD:292299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..102
		FN2	102..148	CDD:128373
		EGF_CA	162..197	CDD:238011
		FN1	200..240	CDD:238018
		EGF_CA	245..278	CDD:238011
		Kringle	286..367	CDD:278480	11/35 (31%)
		Tryp_SPc	414..648	CDD:214473	71/246 (29%)
		Tryp_SPc	415..650	CDD:238113	72/247 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910