Protein Alignment CG6462 and HGF

DIOPT Version :10

• Sequence 1: NP_648011.1
• Gene: CG6462 / 38681
• FlyBaseID: FBgn0035663
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_000592.3
• Gene: HGF / 3082
• HGNCID: 4893
• Length: 728
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 72/282 - (25%)
• Similarity: 110/282 - (39%)
• Gaps: 55/282 - (19%)

  Fly    60 CEKFEMEGNQTAAV--------------RTRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSL 110
            |.....||:.|..:              :.|:..| :.||    ..:|.::.|...:...|||||
Human   464 CPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNG-IPTR----TNIGWMVSLRYRNKHICGGSL 523

  Fly   111 ITLQFVLTAAHCLTDAIAAKIYTGATVFADVEDSVEE--LQVTHRDFIIYPDYLGFGGYSDLALI 173
            |...:||||..|.... ..|.|.......||....:|  .||.:...::|    |..| |||.|:
Human   524 IKESWVLTARQCFPSR-DLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVY----GPEG-SDLVLM 582

  Fly   174 RLPRKVRTSEQVQPIELAGEFMHQNFLVGKVV------TLSGWGYLG----DSTDKRTRLLQYLD 228
            :|.|.....:.|..|:|      .|:  |..:      ::.||||.|    |.      ||:...
Human   583 KLARPAVLDDFVSTIDL------PNY--GCTIPEKTSCSVYGWGYTGLINYDG------LLRVAH 633

  Fly   229 AEVIDQERCICYFLPGLVSQRRHLCTDGSN-GRGACNGDSGGPVVYHWRNVSYLIGVTSFGSAEG 292
            ..::..|:|..:....:......:|..... |.|.|.||.|||:|.....:..::||...|  .|
Human   634 LYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPG--RG 696

  Fly   293 CEV-GGPTVYTRITAYLPWIRQ 313
            |.: ..|.::.|:..|..||.:
Human   697 CAIPNRPGIFVRVAYYAKWIHK 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	67/251 (27%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056	1/5 (20%)
		Tryp_SPc	494..716	CDD:214473	66/248 (27%)