DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and F2

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	89/332 - (26%)
Similarity:	149/332 - (44%)	Gaps:	71/332 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EETPDDDDAIM-------------ERRWQLGYENFRLR--------CEKFEMEGNQTAAVRTRIA 78
            ||..|.|::|.             ||.:.||..:..||        .:|.|.| ...:.:..||.
  Rat   298 EENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKE-LLDSYIDGRIV 361

  Fly    79 GGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCLTDAIAAKIYTGATVFADV-- 141
            .|..|.:|:.|:|| ::.:.|..:|: ||.|||:.::|||||||:......|.:|...:...:
  Rat   362 EGWDAEKGIAPWQV-MLFRKSPQELL-CGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGK 424

  Fly   142 ------EDSVEELQVTHRDFIIYPDYLGFGGYS-DLALIRLPRKVRTSEQVQPIELAGEFMHQNF 199
                  |.:||::.:..:.: |:|.|....... |:||::|.:.|..|:.:.|:.|..:....:.
  Rat   425 HSRTRYERNVEKISMLEKIY-IHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSL 488

  Fly   200 L-VGKVVTLSGWGYLGDS-----TDKRTRLLQYLDAEVIDQERCICYFLPGLVSQRRHLCTD--- 255
            | .|....::|||.|.::     .:.:..:||.::..::  ||.:|      .:..|...||
  Rat   489 LQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIV--ERPVC------KASTRIRITDNMF 545

  Fly   256 ------GSNGRG-ACNGDSGGPVV------YHWRNVSYLIGVTSFGSAEGCEVGGP-TVYTRITA 306
                  ....|| ||.||||||.|      :.|    |.:|:.|:|  |||:..|. ..||.:..
  Rat   546 CAGFKVNDTKRGDACEGDSGGPFVMKSPYNHRW----YQMGIVSWG--EGCDRNGKYGFYTHVFR 604

  Fly   307 YLPWIRQ 313
            ...|:::
  Rat   605 LKRWMQK 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	74/266 (28%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	74/269 (28%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480
		Thrombin_light	312..359	CDD:286482	9/47 (19%)
		Tryp_SPc	359..608	CDD:214473	74/265 (28%)
		Tryp_SPc	360..612	CDD:238113	74/269 (28%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		10/21 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000