DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and F12

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	313	Identity:	97/313 - (30%)
Similarity:	135/313 - (43%)	Gaps:	44/313 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EPWLDTFEHPKEETPDDDDAIMERRWQLGYENFRLRCEKFEMEGNQTAAVRTRIAGGELATRGMF 88
            :|...|...|:.:||....|..|:...| ..|..|.|.:   ...::.:..||:.||.:|.||..
Human   324 KPQPTTRTPPQSQTPGALPAKREQPPSL-TRNGPLSCGQ---RLRKSLSSMTRVVGGLVALRGAH 384

  Fly    89 PYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCLTDAIAAKIYTGATVFADVEDSVEELQ-VTH 152
            ||...|....|     .|.||||...:||||||||.|..|.:..|..........|.|..| :..
Human   385 PYIAALYWGHS-----FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAV 444

  Fly   153 RDFIIYPDYLGFGGYSDLALIRLPRK-----VRTSEQVQPIEL-AGEFMHQNFLVGKVVTLSGWG 211
            |.:.::..:.......||||:||...     ...|..|||:.| :|........:.:|   :|||
Human   445 RSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQV---AGWG 506

  Fly   212 YLGDSTDKRTRLLQYLDAEVIDQERCIC------YFLPGLVSQRRHLCT---DGSNGRGACNGDS 267
            :..:..::....||......:..|||..      ..|||:      ||.   :|  |..||.|||
Human   507 HQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGM------LCAGFLEG--GTDACQGDS 563

  Fly   268 GGPVVYH----WRNVSYLIGVTSFGSAEGC-EVGGPTVYTRITAYLPWIRQQT 315
            |||:|..    .|.:: |.|:.|:||  || :...|.|||.:..||.|||:.|
Human   564 GGPLVCEDQAAERRLT-LQGIISWGS--GCGDRNKPGVYTDVAYYLAWIREHT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	81/255 (32%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	83/257 (32%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		10/35 (29%)
		Tryp_SPc	372..609	CDD:214473	81/255 (32%)
		Tryp_SPc	373..612	CDD:238113	83/257 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910