DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and F9

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_000124.1	Gene:	F9 / 2158	HGNCID:	3551	Length:	461	Species:	Homo sapiens

Alignment Length:	264	Identity:	83/264 - (31%)
Similarity:	128/264 - (48%)	Gaps:	47/264 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TRIAGGELATRGMFPYQVGLVIQLSGADLVKCGGSLITLQFVLTAAHCLTDAIAAKIYTGATVFA 139
            ||:.|||.|..|.||:||    .|:|.....||||::..::::|||||:...:...:..|
Human   225 TRVVGGEDAKPGQFPWQV----VLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAG----- 280

  Fly   140 DVEDSVEELQVTH--RDFI-IYPDY---LGFGGYS-DLALIRLPRKVRTSEQVQPIELAGEFMHQ 197
              |.::||.:.|.  |:.| |.|.:   .....|: |:||:.|...:..:..|.||.:|.:....
Human   281 --EHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTN 343

  Fly   198 NFLVGKVVTLSGWG---YLGDSTDKRTRLLQYLDAEVIDQERCI------CY---FLPGLVSQRR 250
            .||......:||||   :.|.|    ..:||||...::|:..|:      .|   |..|.
Human   344 IFLKFGSGYVSGWGRVFHKGRS----ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF----- 399

  Fly   251 HLCTDGSNGRGACNGDSGGPVVYHWRNVSYLIGVTSFGSAEGCEVGGP-TVYTRITAYLPWIRQQ 314
            |     ..||.:|.||||||.|......|:|.|:.|:|  |.|.:.|. .:||:::.|:.||:::
Human   400 H-----EGGRDSCQGDSGGPHVTEVEGTSFLTGIISWG--EECAMKGKYGIYTKVSRYVNWIKEK 457

  Fly   315 TAMT 318
            |.:|
Human   458 TKLT 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	78/254 (31%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	79/256 (31%)
F9	NP_000124.1	GLA	28..92	CDD:214503
		EGF_CA	93..129	CDD:238011
		FXa_inhibition	134..170	CDD:317114
		Tryp_SPc	227..457	CDD:238113	79/256 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910