DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6462 and Prss12

DIOPT Version :9

Sequence 1:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	270	Identity:	79/270 - (29%)
Similarity:	129/270 - (47%)	Gaps:	52/270 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RIAGGELATRGMFPYQVGLVIQLSGAD-LVKCGGSLITLQFVLTAAHCL------TDAIAAKI-- 131
            ||.||..:.||.:|:|..|.::.:..| .:.||.:|::..:|||||||.      :.:.|.::
Mouse   516 RIIGGNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGD 580

  Fly   132 -YTGATVFADVEDSVEELQVTHRDFIIYPDYLGFGGYSDLALIRL----PRKVRTSEQVQPI--- 188
             :|......:.|..|::: |.||::  .||...:    |:||:||    .:..|.|..|.|.
Mouse   581 YHTLVPEEFEQEIGVQQI-VIHRNY--RPDRSDY----DIALVRLQGPGEQCARLSTHVLPACLP 638

  Fly   189 ------ELAGEFMHQNFLVGKVVTLSGWGYLGDSTDKRTRLLQYLDAEVIDQERCICYFLPGLVS 247
                  :......|          ::||   ||:....:|.||.....::.:..|...: .||.:
Mouse   639 LWRERPQKTASNCH----------ITGW---GDTGRAYSRTLQQAAVPLLPKRFCKERY-KGLFT 689

  Fly   248 QRRHLCTDG---SNGRGACNGDSGGPVVYHWRNVSYLI-GVTSFGSAEGCEV-GGPTVYTRITAY 307
            .|. ||...   .|...:|.||||||::....:.|::: ||||:|  .||.| ..|.||||:.|:
Mouse   690 GRM-LCAGNLQEDNRVDSCQGDSGGPLMCEKPDESWVVYGVTSWG--YGCGVKDTPGVYTRVPAF 751

  Fly   308 LPWIRQQTAM 317
            :|||:..|::
Mouse   752 VPWIKSVTSL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	76/262 (29%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	77/264 (29%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555
		SRCR	396..485	CDD:278931
		Zymogen activation region	505..516		79/270 (29%)
		Tryp_SPc	516..755	CDD:214473	76/262 (29%)
		Tryp_SPc	517..758	CDD:238113	77/264 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000